Evidence map›Paper›PMID 25949945›Full record

ReviewWorld journal of nephrology2015

Species differences in regulation of renal proximal tubule transport by certain molecules.

George Seki, Motonobu Nakamura, Masashi Suzuki, Nobuhiko Satoh, Shoko Horita

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Effects of Nitric Oxide on Renal Proximal Tubular NaBioMed research international · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

George SekiGeorge Seki, Motonobu Nakamura, Masashi Suzuki, Nobuhiko Satoh, Shoko Horita, Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
Motonobu NakamuraGeorge Seki, Motonobu Nakamura, Masashi Suzuki, Nobuhiko Satoh, Shoko Horita, Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
Masashi SuzukiGeorge Seki, Motonobu Nakamura, Masashi Suzuki, Nobuhiko Satoh, Shoko Horita, Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
Nobuhiko SatohGeorge Seki, Motonobu Nakamura, Masashi Suzuki, Nobuhiko Satoh, Shoko Horita, Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
Shoko HoritaGeorge Seki, Motonobu Nakamura, Masashi Suzuki, Nobuhiko Satoh, Shoko Horita, Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
The University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal proximal tubules (PTs) play important roles in the regulation of acid/base, plasma volume and blood pressure. Recent studies suggest that there are substantial species differences in the regulation of PT transport. For example, thiazolidinediones (TZDs) are widely used for the treatment of type 2 diabetes mellitus, but the use of TZDs is associated with fluid overload. In addition to the transcriptional enhancement of sodium transport in distal nephrons, TZDs rapidly stimulate PT sodium transport via a non-genomic mechanism depending on peroxisome proliferator activated receptor γ/Src/epidermal growth factor receptor (EGFR)/MEK/ERK. In mouse PTs, however, TZDs fail to stimulate PT transport probably due to constitutive activation of Src/EGFR/ERK pathway. This unique activation of Src/ERK may also affect the effect of high concentrations of insulin on mouse PT transport. On the other hand, the effect of angiotensin II (Ang II) on PT transport is known to be biphasic in rabbits, rats, and mice. However, Ang II induces a concentration-dependent, monophasic transport stimulation in human PTs. The contrasting responses to nitric oxide/guanosine 3',5'-cyclic monophosphate pathway may largely explain these different effects of Ang II on PT transport. In this review, we focus on the recent findings on the species differences in the regulation of PT transport, which may help understand the species-specific mechanisms underlying edema formation and/or hypertension occurrence.

Indexed as

Angiotensin IIInsulinNitric oxidePeroxisome proliferator activated receptor γRenal proximal tubuleThiazolidinediones

Identifiers

PMID25949945
PMCPMC4419141
OpenAlexW2162059875

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.