Evidence map›Paper›PMID 25949916›Full record

ArticleOncoimmunology2015

Novel role of hematopoietic stem cells in immunologic rejection of malignant gliomas.

Catherine Flores, Christina Pham, David Snyder, Shicheng Yang, Luis Sanchez-Perez, Elias Sayour, Xiuyu Cui, Hanna Kemeny, Henry Friedman, Darell D Bigner and 2 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Rewriting microenvironment immunity in glioblastoma.Molecular therapy. Oncology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Advanced Cell Therapies for Glioblastoma.Frontiers in immunology · 2022
    Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Catherine FloresUF Brain Tumor Immunotherapy Program; Preston A. Wells, Jr. Center for Brain Tumor Therapy; Department of Neurosurgery; University of Florida ; Gainesville, FL, USA.
Christina PhamUF Brain Tumor Immunotherapy Program; Preston A. Wells, Jr. Center for Brain Tumor Therapy; Department of Neurosurgery; University of Florida ; Gainesville, FL, USA.
David SnyderDivision of Neurosurgery; Department of Surgery; Duke University Medical Center ; Durham, NC, USA.
Shicheng YangDivision of Neurosurgery; Department of Surgery; Duke University Medical Center ; Durham, NC, USA.
Luis Sanchez-PerezDivision of Neurosurgery; Department of Surgery; Duke University Medical Center ; Durham, NC, USA.
Elias SayourUF Brain Tumor Immunotherapy Program; Preston A. Wells, Jr. Center for Brain Tumor Therapy; Department of Neurosurgery; University of Florida ; Gainesville, FL, USA.
Xiuyu CuiDivision of Neurosurgery; Department of Surgery; Duke University Medical Center ; Durham, NC, USA.
Hanna KemenyDivision of Neurosurgery; Department of Surgery; Duke University Medical Center ; Durham, NC, USA.
Henry FriedmanDivision of Neurosurgery; Department of Surgery; Duke University Medical Center ; Durham, NC, USA.
Darell D BignerDepartment of Pathology; Duke University Medical Center ; Durham, NC, USA.
John SampsonDivision of Neurosurgery; Department of Surgery; Duke University Medical Center ; Durham, NC, USA ; Department of Pathology; Duke University Medical Center ; Durham, NC, USA.
Duane A MitchellUF Brain Tumor Immunotherapy Program; Preston A. Wells, Jr. Center for Brain Tumor Therapy; Department of Neurosurgery; University of Florida ; Gainesville, FL, USA.
Duke Medical Center · USUniversity of Florida · US

Funding

Training Program in Developmental & Stem Cell BiologyT32HD040372 · NICHD · DUKE UNIVERSITY · PI Terry H Lechler · 2001 to 2026
$8.9M
NICHD NIH HHS T32 HD040372
6 · The paper itself

Abstract

Adoptive cellular therapy (ACT) after lymphodepletive conditioning can induce dramatic clinical responses, but this approach has been largely limited to melanoma due to a lack of reliable methods for expanding tumor-specific lymphocytes from the majority of other solid cancers. We have employed tumor RNA-pulsed dendritic cells (DCs) to reliably expand CD4

Indexed as

ACT, adoptive cellular therapyCAR, chimeric antigen receptorCBA, cytokine bead arrayCCL3, (MIP1α) macrophage inhibitory protein 1cellular therapyCXCL12, (SDF1) stromal derived factor 1DC, dendritic cellFACS, fluorescence activated cell sortingGBMglioblastomagliomahematopoietic stem cellsHSC, haematopoietic stem cellIFNγ, interferon gammaIL-15, interleukin 15IL-7, interleukin 7immunotherapyMA, myeloablativeNMA, non-myeloablativeOVA, ovalbuminSEM, standard error of meanTAA, tumor associated antigensTCR, T cell receptorTMZ, temozolomideTNFα, tumor necrosis factor αTTRNA-T cells, tumor-specific T cells activated ex vivo using RNA-pulsed DCsWBI, whole brain irradiation.

Identifiers

PMID25949916
PMCPMC4404923
OpenAlexW2078717875

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.