Evidence map›Paper›PMID 25949914›Full record

ArticleOncoimmunology2015

Dang Wu, Pin Wu, Xianguo Wu, Jun Ye, Zhen Wang, Shuai Zhao, Chao Ni, Guoming Hu, Jinghong Xu, Yuehua Han and 4 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 93 citations in OpenAlex.

  1. γδ T cells in colorectal and liver cancer.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  2. Article
  3. Review
  4. Harnessing Vδ1Frontiers in immunology · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. A GD (Gamma-Delta) type of cancel culture.Immuno-oncology technology · 2024
    Review
  10. Review
  11. The Double-Edged Sword Property of Mesenchymal Stem Cell-Derived Exosomal microRNAs in Colorectal Cancer.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024
    Review
  12. Article
  13. Review
  14. Controversial role of γδ T cells in colorectal cancer.American journal of cancer research · 2024
    Review
  15. Review
  16. Review
  17. Review
  18. Cord blood-derived VScience advances · 2023
    Article
  19. Review
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 4 countries.

Dang WuCancer Institute (Key Laboratory of Cancer Prevention & Intervention; National Ministry of Education; Provincial Key Laboratory of Molecular Biology in Medical Sciences), Second Affiliated Hospital; Zhejiang University School of Medicine ; Hangzhou, China ; Department of Oncology; Second Affiliated Hospital; Zhejiang University School of Medicine; Zhejiang University , Hangzhou, China.
Pin WuCancer Institute (Key Laboratory of Cancer Prevention & Intervention; National Ministry of Education; Provincial Key Laboratory of Molecular Biology in Medical Sciences), Second Affiliated Hospital; Zhejiang University School of Medicine ; Hangzhou, China ; Department of Oncology; Second Affiliated Hospital; Zhejiang University School of Medicine; Zhejiang University , Hangzhou, China ; Department of Thoracic Surgery; Second Affiliated Hospital; Zhejiang University School of Medicine; Zhejiang University , Hangzhou, China.
Xianguo WuDepartment of Clinical Laboratory; Second Affiliated Hospital; Zhejiang University School of Medicine; Zhejiang University , Hangzhou, China.
Jun YeCancer Institute (Key Laboratory of Cancer Prevention & Intervention; National Ministry of Education; Provincial Key Laboratory of Molecular Biology in Medical Sciences), Second Affiliated Hospital; Zhejiang University School of Medicine ; Hangzhou, China ; Department of Gastroenterology; Second Affiliated Hospital; Zhejiang University School of Medicine; Zhejiang University , Hangzhou, China.
Zhen WangCancer Institute (Key Laboratory of Cancer Prevention & Intervention; National Ministry of Education; Provincial Key Laboratory of Molecular Biology in Medical Sciences), Second Affiliated Hospital; Zhejiang University School of Medicine ; Hangzhou, China ; Department of Oncology; Second Affiliated Hospital; Zhejiang University School of Medicine; Zhejiang University , Hangzhou, China.
Shuai ZhaoCancer Institute (Key Laboratory of Cancer Prevention & Intervention; National Ministry of Education; Provincial Key Laboratory of Molecular Biology in Medical Sciences), Second Affiliated Hospital; Zhejiang University School of Medicine ; Hangzhou, China ; Department of Oncology; Second Affiliated Hospital; Zhejiang University School of Medicine; Zhejiang University , Hangzhou, China.
Chao NiCancer Institute (Key Laboratory of Cancer Prevention & Intervention; National Ministry of Education; Provincial Key Laboratory of Molecular Biology in Medical Sciences), Second Affiliated Hospital; Zhejiang University School of Medicine ; Hangzhou, China ; Department of Oncology; Second Affiliated Hospital; Zhejiang University School of Medicine; Zhejiang University , Hangzhou, China.
Guoming HuCancer Institute (Key Laboratory of Cancer Prevention & Intervention; National Ministry of Education; Provincial Key Laboratory of Molecular Biology in Medical Sciences), Second Affiliated Hospital; Zhejiang University School of Medicine ; Hangzhou, China ; Department of Oncology; Second Affiliated Hospital; Zhejiang University School of Medicine; Zhejiang University , Hangzhou, China.
Jinghong XuDepartment of Pathology; Second Affiliated Hospital; Zhejiang University School of Medicine; Zhejiang University ; Hangzhou, China.
Yuehua HanDepartment of Gastroenterology; Second Affiliated Hospital; Zhejiang University School of Medicine; Zhejiang University , Hangzhou, China.
Ting ZhangDepartment of Radiation Oncology; Second Affiliated Hospital; Zhejiang University School of Medicine; Zhejiang University , Hangzhou, China.
Fuming QiuCancer Institute (Key Laboratory of Cancer Prevention & Intervention; National Ministry of Education; Provincial Key Laboratory of Molecular Biology in Medical Sciences), Second Affiliated Hospital; Zhejiang University School of Medicine ; Hangzhou, China ; Department of Oncology; Second Affiliated Hospital; Zhejiang University School of Medicine; Zhejiang University , Hangzhou, China.
Jun YanDepartment of Medicine and Department of Microbiology and Immunology; James Graham Brown Cancer Center; University of Louisville ; Louisville, KY, USA.
Jian HuangCancer Institute (Key Laboratory of Cancer Prevention & Intervention; National Ministry of Education; Provincial Key Laboratory of Molecular Biology in Medical Sciences), Second Affiliated Hospital; Zhejiang University School of Medicine ; Hangzhou, China ; Department of Oncology; Second Affiliated Hospital; Zhejiang University School of Medicine; Zhejiang University , Hangzhou, China.
Cancer Institute (WIA) · INZhejiang University · CNMRC Laboratory of Molecular Biology · GBJames Graham Brown Foundation · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gamma delta T (γδT) cells are innate-like lymphocytes with strong, MHC-unrestricted cytotoxicity against cancer cells and show a promising prospect in adoptive cellular immunotherapy for various malignancies. However, the clinical outcome of commonly used Vγ9Vδ2 γδT (Vδ2 T) cells in adoptive immunotherapy for most solid tumors is limited. Here, we demonstrate that freshly isolated Vδ1 γδT (Vδ1 T) cells from human peripheral blood (PB) exhibit more potent cytotoxicity against adherent and sphere-forming human colon cancer cells than Vδ2 T cells

Indexed as

adoptive cellular immunotherapyAntigens, Ags; CCSCs, colon cancer stem cells; FACS, fluorescence activated cell sorting; FCM, flow cytometry; γδT cells, gamma delta T cells; IL-7, interleukin-7; MACS, magnetic activated cell sorting; PB, peripheral blood; PHA, phytohemagglutinin; PBMCs, peripheral blood mononuclear cells; Vδ2 T cells, Vγ9Vδ2 γδT cells; Vδ1 T cells, Vδ1 γδT cells; Zol, Zoledronate.cytotoxicityhuman colon cancerhuman PB Vδ1 T cellshuman PB Vδ2 T cells

Identifiers

PMID25949914
PMCPMC4404819
OpenAlexW1999682996

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.