Evidence map›Paper›PMID 25949906›Full record

ArticleOncoimmunology2015

Tumor-associated and immunochemotherapy-dependent long-term alterations of the peripheral blood NK cell compartment in DLBCL patients.

M Christina Cox, Simone Battella, Raffaella La Scaleia, Sabrina Pelliccia, Arianna Di Napoli, Alessandra Porzia, Francesca Cecere, Eleonora Alma, Alessandra Zingoni, Fabrizio Mainiero and 4 more

Abstract read
In one paragraph

Article in Oncoimmunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. NADPharmaceutical science advances · 2026
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  9. What Inhibits Natural Killers' Performance in Tumour.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

M Christina CoxHematology Unit; Sant'Andrea Hospital; Sapienza University ; Rome, Italy.
Simone BattellaDepartment of Experimental Medicine; Sapienza University ; Rome, Italy.
Raffaella La ScaleiaDepartment of Experimental Medicine; Sapienza University ; Rome, Italy.
Sabrina PellicciaHematology Unit; Sant'Andrea Hospital; Sapienza University ; Rome, Italy.
Arianna Di NapoliDepartment of Clinical and Molecular Medicine; Sapienza University ; Rome, Italy.
Alessandra PorziaDepartment of Molecular Medicine; Sapienza University ; Rome, Italy.
Francesca CecereDepartment of Molecular Medicine; Sapienza University ; Rome, Italy.
Eleonora AlmaHematology Unit; Sant'Andrea Hospital; Sapienza University ; Rome, Italy.
Alessandra ZingoniDepartment of Molecular Medicine; Sapienza University ; Rome, Italy.
Fabrizio MainieroDepartment of Experimental Medicine; Sapienza University ; Rome, Italy.
Luigi RucoDepartment of Clinical and Molecular Medicine; Sapienza University ; Rome, Italy.
Bruno MonarcaHematology Unit; Sant'Andrea Hospital; Sapienza University ; Rome, Italy.
Angela SantoniDepartment of Molecular Medicine; Sapienza University ; Rome, Italy ; Istituto Pasteur-Fondazione Cenci Bolognetti; Sapienza University ; Rome, Italy.
Gabriella PalmieriDepartment of Experimental Medicine; Sapienza University ; Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural Killer (NK) cells are a key component of tumor immunosurveillance and thus play an important role in rituximab-dependent killing of lymphoma cells via an antibody-dependent cellular cytotoxicity (ADCC) mechanism. We evaluated the phenotypic and functional assets of peripheral blood NK cell subsets in 32 newly-diagnosed diffuse large B-cell lymphoma (DLBCL) patients and in 27 healthy controls. We further monitored long-term modifications of patient NK cells for up to 12 months after rituximab-based immunochemotherapy. At diagnosis, patients showed a higher percentage of CD56

Indexed as

ADCCADCC, antibody-dependent cellular cytotoxicity; CNS, central nervous system; DLBCL, diffuse large B-cell lymphoma; FcγRIIIA/CD16, type III low-affinity Fcγ receptor; GrzB, Granzyme B; IFNγ, interferon γ; NK, natural killer cells; PBMC, peripheral blood mononuclear cell; PMLBCL, primary mediastinal large B-cell lymphoma; R-CHOP, rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone.CD16DLBCLNK cellsNKG2DR-CHOP immunochemotherapyrituximab

Identifiers

PMID25949906
PMCPMC4404844

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.