Evidence map›Paper›PMID 25949894›Full record

ArticleOncoimmunology2015

An immunogenomic stratification of colorectal cancer: Implications for development of targeted immunotherapy.

Neeraj Lal, Andrew D Beggs, Benjamin E Willcox, Gary W Middleton

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 123 citations in OpenAlex.

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  15. TheCancers · 2023
    Article
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Neeraj LalCancer Immunology and Immunotherapy Centre; School of Cancer Sciences; University of Birmingham ; Birmingham, UK.
Andrew D BeggsCancer Immunology and Immunotherapy Centre; School of Cancer Sciences; University of Birmingham ; Birmingham, UK.
Benjamin E WillcoxCancer Immunology and Immunotherapy Centre; School of Cancer Sciences; University of Birmingham ; Birmingham, UK.
Gary W MiddletonCancer Immunology and Immunotherapy Centre; School of Cancer Sciences; University of Birmingham ; Birmingham, UK.
University of Birmingham · GB

Funding

Medical Research Council MR/M009157/1Wellcome Trust 099266/Z/12/Z
6 · The paper itself

Abstract

Although tumor infiltrating lymphocyte (TIL) density is prognostic and predictive in colorectal cancer (CRC), the impact of tumor genetics upon colorectal immunobiology is unclear. Identification of genetic factors that influence the tumor immunophenotype is essential to improve the effectiveness of stratified immunotherapy approaches. We carried out a bioinformatics analysis of CRC data in The Cancer Genome Atlas (TCGA) involving two-dimensional hierarchical clustering to define an immune signature that we used to characterize the immune response across key patient groups. An immune signature termed The Co-ordinate Immune Response Cluster (CIRC) comprising 28 genes was coordinately regulated across the patient population. Four patient groups were delineated on the basis of cluster expression. Group A, which was heavily enriched for patients with microsatellite instability (MSI-H) and POL mutations, exhibited high CIRC expression, including the presence of several inhibitory molecules:

Indexed as

CIRC, Co-ordinate Immune Response ClusterCMS, consensus molecular subtypescolorectal cancerCRC, colorectal cancerCRCSC, colorectal cancer subtyping consortiumimmune signaturemicrosatellite instabilityMSI-H, microsatellite unstable (high)MSI-L, microsatellite unstable (low)MSS, microsatellite stableRASstratificationTCGA, The Cancer Genome AtlasTILs, tumor-infiltrating lymphocytes

Identifiers

PMID25949894
PMCPMC4404815
OpenAlexW2040229544

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.