Evidence map›Paper›PMID 25949882›Full record

ReviewOncoimmunology2015

Potential of autologous NK cell therapy to eradicate leukemia: "Education is [not] the best provision for old age" -Aristotle.

Hisham Abdel-Azim, Nora Heisterkamp

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oncoimmunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hisham Abdel-AzimDivision of Hematology/Oncology and Bone Marrow Transplantation; Department of Pediatrics; The Saban Research Institute of Children's Hospital Los Angeles ; CA USA.
Nora HeisterkampSection of Molecular Carcinogenesis ; CA USA ; Division of Hematology/Oncology and Bone Marrow Transplantation; Department of Pediatrics; The Saban Research Institute of Children's Hospital Los Angeles ; CA USA ; Leukemia and Lymphoma Program; Norris Comprehensive Cancer Center; University of Southern California ; CA USA.

Funding

TREATMENT OF BCR/ABL CAUSED LEUKEMIAS WITH FTIsR01CA090321 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI HEISTERKAMP, NORA C · 2001 to 2017
$4.4M
Microenvironment-Leukemia Communication Through LectinsR01CA172040 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI GROFFEN, JOHN H, HEISTERKAMP, NORA C · 2013 to 2017
$1.7M
NCI NIH HHS R01 CA090321NCI NIH HHS R01 CA172040
6 · The paper itself

Abstract

B-precursor acute lymphoblastic leukemia (BP-ALL) patients are immunocompromised. We recently reported that functional natural killer (NK) cells can be grown from patient bone marrow and blood samples at diagnosis. Surprisingly, such NK cells exhibit cytotoxicity against autologous BP-ALL cells. Here, we outline unanswered questions, challenges and possible applications associated with these findings.

Indexed as

ADCCadoptive cell therapyartificial antigen presentingautologousBP-ALLexpanded NKpre-B ALL

Identifiers

PMID25949882
PMCPMC4404799

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.