Evidence map›Paper›PMID 25949264›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2015

Chemical Composition and Larvicidal Activity of Essential Oils Extracted from Brazilian Legal Amazon Plants against Aedes aegypti L. (Diptera: Culicidae).

Clarice Noleto Dias, Luciana Patrícia Lima Alves, Klinger Antonio da Franca Rodrigues, Maria Cristiane Aranha Brito, Carliane Dos Santos Rosa, Flavia Maria Mendonça do Amaral, Odair Dos Santos Monteiro, Eloisa Helena de Aguiar Andrade, José Guilherme Soares Maia, Denise Fernandes Coutinho Moraes

Abstract read
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Systematic Review of the Ovitrap Surveillance ofTropical medicine and infectious disease · 2025
    Review
  2. Article
  3. Article
  4. Larvicidal Effect ofMolecules (Basel, Switzerland) · 2022
    Article
  5. Review
  6. Article
  7. The Toxicity ofToxins · 2022
    Article
  8. Insecticidal, Antimalarial, and Antileishmanial Effects of Royal Jelly and Its Three Main Fatty Acids,Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  9. Chemical Composition and Insecticidal, Antiplasmodial, and Anti-Leishmanial Activity ofEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
  10. Article
  11. Monoterpenes and Sesquiterpenes of Essential Oils fromMolecules (Basel, Switzerland) · 2021
    Review
  12. Larvicidal Activity of Essential Oils FromFrontiers in plant science · 2021
    Article
  13. Essentials Oils from BrazilianBiomolecules · 2020
    Review
  14. Article
  15. Larvicidal activity ofJournal of experimental pharmacology · 2019
    Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Clarice Noleto DiasPrograma de Pós-Graduação em Saúde e Ambiente, Universidade Federal do Maranhão, 65085-580 São Luís, MA, Brazil.
Luciana Patrícia Lima AlvesPrograma de Pós-Graduação em Saúde e Ambiente, Universidade Federal do Maranhão, 65085-580 São Luís, MA, Brazil.
Klinger Antonio da Franca RodriguesDepartamento de Farmácia, Universidade Federal do Maranhão, 65085-580 São Luís, MA, Brazil.
Maria Cristiane Aranha BritoDepartamento de Farmácia, Universidade Federal do Maranhão, 65085-580 São Luís, MA, Brazil.
Carliane Dos Santos RosaDepartamento de Farmácia, Universidade Federal do Maranhão, 65085-580 São Luís, MA, Brazil.
Flavia Maria Mendonça do AmaralDepartamento de Farmácia, Universidade Federal do Maranhão, 65085-580 São Luís, MA, Brazil.
Odair Dos Santos MonteiroPrograma de Pós-Graduação em Química, Universidade Federal do Maranhão, 65085-580 São Luís, MA, Brazil.
Eloisa Helena de Aguiar AndradePrograma de Pós-Graduação em Química, Universidade Federal do Pará, 66075-900 Belém, PA, Brazil.
José Guilherme Soares MaiaPrograma de Pós-Graduação em Recursos Naturais da Amazônia, Universidade Federal do Oeste do Pará, 68035-110 Santarém, PA, Brazil.
Denise Fernandes Coutinho MoraesPrograma de Pós-Graduação em Saúde e Ambiente, Universidade Federal do Maranhão, 65085-580 São Luís, MA, Brazil ; Departamento de Farmácia, Universidade Federal do Maranhão, 65085-580 São Luís, MA, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mosquito Aedes aegypti L. (Diptera: Culicidae) is the major vector of dengue and chikungunya fever. The lack of effective therapies and vaccines for these diseases highlights the need for alternative strategies to control the spread of virus. Therefore, this study investigated the larvicidal potential of essential oils from common plant species obtained from the Chapada das Mesas National Park, Brazil, against third instar A. aegypti larvae. The chemical composition of these oils was determined by gas chromatography coupled to mass spectrometry. The essential oils of Eugenia piauhiensis Vellaff., Myrcia erythroxylon O. Berg, Psidium myrsinites DC., and Siparuna camporum (Tul.) A. DC. were observed to be mainly composed of sesquiterpene hydrocarbons. The essential oil of Lippia gracilis Schauer was composed of oxygenated monoterpenes. Four of the five tested oils were effective against the A. aegypti larvae, with the lethal concentration (LC50) ranging from 230 to 292 mg/L after 24 h of exposure. Overall, this work demonstrated the possibility of developing larvicidal products against A. aegypti by using essential oils from the flora of the Brazilian Legal Amazon. This in turn demonstrates the potential of using natural resources for the control of disease vectors.

Identifiers

PMID25949264
PMCPMC4408633

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.