ArticleJournal of inflammation (London, England)2015
Mucus mediated protection against acute colitis in adiponectin deficient mice.
Article in Journal of inflammation (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Adiponectin deficiency prevents chronic colitis-associated colonic fibrosis via inhibiting CXCL13 production.Journal of advanced research · 2025Article
- Western Diet Promotes Intestinal Colonization by Collagenolytic Microbes and Promotes Tumor Formation After Colorectal Surgery.Gastroenterology · 2020Article
- Role of Obesity, Mesenteric Adipose Tissue, and Adipokines in Inflammatory Bowel Diseases.Biomolecules · 2019Review
- Low Molecular Weight Adiponectin Increases the Mortality Risk in Very Old Patients.Aging and disease · 2018Article
- Antibiotic-mediated bacteriome depletion in ApcCancer medicine · 2018Article
- Adiponectin and adiponectin receptor 1 overexpression enhance inflammatory bowel disease.Journal of biomedical science · 2018Article
- Adiponectin confers protection from acute colitis and restricts a B cell immune response.The Journal of biological chemistry · 2017Article
- Adiponectin and colorectal cancer.Surgery today · 2017Review
- Evidence of a causal relationship between high serum adiponectin levels and increased cardiovascular mortality rate in patients with type 2 diabetes.Cardiovascular diabetology · 2016Article
- Adipokines and the role of visceral adipose tissue in inflammatory bowel disease.Annals of gastroenterologyReview
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAcute ulcerative colitis is an inflammation-driven condition of the bowel. It hampers the general homeostasis of gut, resulting in decreased mucus production and epithelial cell renewal. Adiponectin (APN), an adipocytokine, is secreted by the adipose tissue and has been debated both as a pro-inflammatory or anti-inflammatory protein depending on the disease condition and microenvironment. The present study delineates the role of APN depletion in mucus modulation in a model of acute colitis.
methodsAPNKO and C57BL/6 (WT) male mice were given 2% DSS ad libidum for 5 days in drinking water, followed by normal drinking water for the next 5 days. Hematoxyline-eosin and Alcian Blue staining was used to observe the general colonic morphology and goblet cell quantification respectively. Protein expression levels were quantified by Western blot for MATH1, Hes1, MUC2 and MUC4. ELISA was used to study the levels of TNF-α, IL-6 and IL-1β.
resultsAPNKO mice showed significantly higher goblet to epithelial cell ratios, lower pro-inflammatory cytokines and higher MUC2 levels as compared to the WT mice. The protein expression levels for the mucin MUC2 supported the histopathological findings. An increase in colon tissue-secreted levels of pro-inflammatory with a reduction in anti-inflammatory cytokines in presence of APN support the pro-inflammatory role of APN during acute inflammation.
conclusionAbsence of APN is protective against DSS-induced acute colonic inflammation by means of reducing colon tissue-secreted pro-inflammatory cytokines, modulating goblet and epithelial cell expressions, and increasing the levels of secretory mucin MUC2.
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