ArticleNucleic acids research2015
antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters.
Article in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,020 papers.
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Who cites it
1,020 citing papers in PubMed.
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- The antiSMASH database version 5.Nucleic acids research · 2026Article
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- Dual-probe genome mining identifies citrulassin N, a novel citrulline modified lasso peptide fromFrontiers in microbiology · 2026Article
- High-Throughput Prediction of Protein-Protein Interactions Uncovers Hidden Molecular Networks in Biosynthetic Gene Clusters.Computational and structural biotechnology journal · 2026Article
- Genomic sequencing of vineyard-isolatedFrontiers in microbiology · 2026Article
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- Antifungal activity and genome annotation of Bacillus amyloliquefaciens subsp. plantarum SMLR1, a potential biocontrol agent of Rhizoctonia solani.World journal of microbiology & biotechnology · 2025Article
- The Role of Nucleotide Sequencing in Natural Product Drug Discovery.Journal of natural products · 2025Review
- Genomic characterization and analysis of Fusarium Solani isolate 1-Jan, a novel pathogenic strain infecting Penaeus vannamei.Current genetics · 2025Article
- Isolation of a NovelMicroorganisms · 2025Article
- Untargeted GC-MS Metabolic Profiling of Anaerobic Gut Fungi Reveals Putative Terpenoids and Strain-Specific Metabolites.Metabolites · 2025Article
- antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation.Nucleic acids research · 2025Article
- Regulatory orchestration of FK506 biosynthesis iniScience · 2025Article
- Synthesis of Lipopeptides Using Vegetable Oils by Newly Isolated Strain ofInternational journal of molecular sciences · 2025Article
960 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors.
Funding
Abstract
Microbial secondary metabolism constitutes a rich source of antibiotics, chemotherapeutics, insecticides and other high-value chemicals. Genome mining of gene clusters that encode the biosynthetic pathways for these metabolites has become a key methodology for novel compound discovery. In 2011, we introduced antiSMASH, a web server and stand-alone tool for the automatic genomic identification and analysis of biosynthetic gene clusters, available at http://antismash.secondarymetabolites.org. Here, we present version 3.0 of antiSMASH, which has undergone major improvements. A full integration of the recently published ClusterFinder algorithm now allows using this probabilistic algorithm to detect putative gene clusters of unknown types. Also, a new dereplication variant of the ClusterBlast module now identifies similarities of identified clusters to any of 1172 clusters with known end products. At the enzyme level, active sites of key biosynthetic enzymes are now pinpointed through a curated pattern-matching procedure and Enzyme Commission numbers are assigned to functionally classify all enzyme-coding genes. Additionally, chemical structure prediction has been improved by incorporating polyketide reduction states. Finally, in order for users to be able to organize and analyze multiple antiSMASH outputs in a private setting, a new XML output module allows offline editing of antiSMASH annotations within the Geneious software.
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