Evidence map›Paper›PMID 25948401›Full record

ArticleBMC genomics2015

Molecular tools to support metabolic and immune function research in the Guinea Fowl (Numida meleagris).

Carl E Darris, James E Tyus, Gary Kelley, Alexander J Ropelewski, Hugh B Nicholas, Xiaofei Wang, Samuel Nahashon

Open access · goldAbstract read
In one paragraph

Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Carl E DarrisCollege of Agriculture, Human and Natural Sciences, Tennessee State University, Nashville, Tennessee, USA. carldarris@gmail.com.
James E TyusCollege of Agriculture, Human and Natural Sciences, Tennessee State University, Nashville, Tennessee, USA. JTYUS615@gmail.com.
Gary KelleyCollege of Agriculture, Human and Natural Sciences, Tennessee State University, Nashville, Tennessee, USA. gkelley82@gmail.com.
Alexander J RopelewskiPittsburgh Supercomputing Center, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA. ropelews@psc.edu.
Hugh B NicholasPittsburgh Supercomputing Center, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA. hugh_67@msn.com.
Xiaofei WangCollege of Agriculture, Human and Natural Sciences, Tennessee State University, Nashville, Tennessee, USA. xwang@tnstate.edu.
Samuel NahashonCollege of Agriculture, Human and Natural Sciences, Tennessee State University, Nashville, Tennessee, USA. snahashon@tnstate.edu.
Tennessee State University · USPittsburgh Supercomputing Center · US

Funding

Bioinformatics Programs at Minority InstitutionsT36GM095335 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI ROPELEWSKI, ALEXANDER J · 2011 to 2015
$3.2M
NIGMS NIH HHS T36 GM095335NIGMS NIH HHS T36-GM-095335
6 · The paper itself

Abstract

backgroundGuinea fowl (Numidia meleagris) production as an alternative source of meat and poultry has shown potential for economic viability. However, there has been little progress in characterizing the transcriptome of the guinea fowl. In this study RNA-sequencing and de novo transcriptome assembly of several Guinea fowl tissues (pancreas, hypothalamus, liver, bone marrow and bursa) which play key roles in regulating feed intake, satiety, and immune function was performed using Illumina's Hi-Seq 2000.

results74 million sequences were generated and assembled into 96,492 contigs using the Trinity software suite. Over 39,000 of these transcripts were found to have in silico translated protein sequences that are homologous to chicken protein sequences. Gene ontology analysis uncovered 416 transcripts with metabolic functions and 703 with immune function.

conclusionThe transcriptome information presented here will support the development of molecular approaches to improve production efficiency of the guinea fowl and other avian species.

Indexed as

Gene Expression ProfilingAnimalsDatabases, GeneticGalliformesMolecular Sequence AnnotationOrgan SpecificitySequence Analysis, RNASequence Homology, Nucleic AcidSoftware

Identifiers

PMID25948401
PMCPMC4432510
OpenAlexW1510271922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.