Evidence map›Paper›PMID 25948271›Full record

Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2015

Longitudinal changes in adolescent risk-taking: a comprehensive study of neural responses to rewards, pubertal development, and risk-taking behavior.

Barbara R Braams, Anna C K van Duijvenvoorde, Jiska S Peper, Eveline A Crone

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 301 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
301citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

301 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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241 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Barbara R BraamsInstitute of Psychology, Leiden University, 2333 AK, Leiden, The Netherlands, and Leiden Institute for Brain and Cognition, 2300 RC, Leiden, The Netherlands B.R.Braams@fsw.leidenuniv.nl.
Anna C K van DuijvenvoordeInstitute of Psychology, Leiden University, 2333 AK, Leiden, The Netherlands, and Leiden Institute for Brain and Cognition, 2300 RC, Leiden, The Netherlands.
Jiska S PeperInstitute of Psychology, Leiden University, 2333 AK, Leiden, The Netherlands, and Leiden Institute for Brain and Cognition, 2300 RC, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-3627-5343
Eveline A CroneInstitute of Psychology, Leiden University, 2333 AK, Leiden, The Netherlands, and Leiden Institute for Brain and Cognition, 2300 RC, Leiden, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prior studies have highlighted adolescence as a period of increased risk-taking, which is postulated to result from an overactive reward system in the brain. Longitudinal studies are pivotal for testing these brain-behavior relations because individual slopes are more sensitive for detecting change. The aim of the current study was twofold: (1) to test patterns of age-related change (i.e., linear, quadratic, and cubic) in activity in the nucleus accumbens, a key reward region in the brain, in relation to change in puberty (self-report and testosterone levels), laboratory risk-taking and self-reported risk-taking tendency; and (2) to test whether individual differences in pubertal development and risk-taking behavior were contributors to longitudinal change in nucleus accumbens activity. We included 299 human participants at the first time point and 254 participants at the second time point, ranging between ages 8-27 years, time points were separated by a 2 year interval. Neural responses to rewards, pubertal development (self-report and testosterone levels), laboratory risk-taking (balloon analog risk task; BART), and self-reported risk-taking tendency (Behavior Inhibition System/Behavior Activation System questionnaire) were collected at both time points. The longitudinal analyses confirmed the quadratic age pattern for nucleus accumbens activity to rewards (peaking in adolescence), and the same quadratic pattern was found for laboratory risk-taking (BART). Nucleus accumbens activity change was further related to change in testosterone and self-reported reward-sensitivity (BAS Drive). Thus, this longitudinal analysis provides new insight in risk-taking and reward sensitivity in adolescence: (1) confirming an adolescent peak in nucleus accumbens activity, and (2) underlining a critical role for pubertal hormones and individual differences in risk-taking tendency.

Indexed as

RewardRisk-TakingAdolescentAdolescent BehaviorAdolescent DevelopmentAdultChildFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleNucleus AccumbensPubertyYoung Adultadolescencepubertyreward processingrisk-taking

Identifiers

PMID25948271
PMCPMC6605271

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.