ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Trunk robot rehabilitation training with active stepping reorganizes and enriches trunk motor cortex representations in spinal transected rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Mechanism-Based Neuromodulation in Augmenting Respiratory Motor Function in Individuals with Spinal Cord Injury.Journal of clinical medicine · 2025Review
- Article
- Rehabilitation Training after Spinal Cord Injury Affects Brain Structure and Function: From Mechanisms to Methods.Biomedicines · 2023Review
- Hindlimb Somatosensory Information Influences Trunk Sensory and Motor Cortices to Support Trunk Stabilization.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- A narrative review of machine learning as promising revolution in clinical practice of scoliosis.Annals of translational medicine · 2021Review
- Respiratory Training and Plasticity After Cervical Spinal Cord Injury.Frontiers in cellular neuroscience · 2021Review
- Transplanting neural progenitor cells to restore connectivity after spinal cord injury.Nature reviews. Neuroscience · 2020Review
- From cortex to cord: motor circuit plasticity after spinal cord injury.Neural regeneration research · 2019Review
- Motor primitives are determined in early development and are then robustly conserved into adulthood.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- A rodent brain-machine interface paradigm to study the impact of paraplegia on BMI performance.Journal of neuroscience methods · 2018Article
- Cortical Reorganization of Sensorimotor Systems and the Role of Intracortical Circuits After Spinal Cord Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Review
- Post-stroke kinematic analysis in rats reveals similar reaching abnormalities as humans.Scientific reports · 2018Article
- Cortex-dependent recovery of unassisted hindlimb locomotion after complete spinal cord injury in adult rats.eLife · 2017Article
- What Did We Learn from the Animal Studies of Body Weight-Supported Treadmill Training and Where Do We Go from Here?Journal of neurotrauma · 2017Review
- Enhancing neural activity to drive respiratory plasticity following cervical spinal cord injury.Experimental neurology · 2017Review
- Engagement of the Rat Hindlimb Motor Cortex across Natural Locomotor Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Teaching Adult Rats Spinalized as Neonates to Walk Using Trunk Robotic Rehabilitation: Elements of Success, Failure, and Dependence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
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2 authors.
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Abstract
Trunk motor control is crucial for postural stability and propulsion after low thoracic spinal cord injury (SCI) in animals and humans. Robotic rehabilitation aimed at trunk shows promise in SCI animal models and patients. However, little is known about the effect of SCI and robot rehabilitation of trunk on cortical motor representations. We previously showed reorganization of trunk motor cortex after adult SCI. Non-stepping training also exacerbated some SCI-driven plastic changes. Here we examine effects of robot rehabilitation that promotes recovery of hindlimb weight support functions on trunk motor cortex representations. Adult rats spinal transected as neonates (NTX rats) at the T9/10 level significantly improve function with our robot rehabilitation paradigm, whereas treadmill-only trained do not. We used intracortical microstimulation to map motor cortex in two NTX groups: (1) treadmill trained (control group); and (2) robot-assisted treadmill trained (improved function group). We found significant robot rehabilitation-driven changes in motor cortex: (1) caudal trunk motor areas expanded; (2) trunk coactivation at cortex sites increased; (3) richness of trunk cortex motor representations, as examined by cumulative entropy and mutual information for different trunk representations, increased; (4) trunk motor representations in the cortex moved toward more normal topography; and (5) trunk and forelimb motor representations that SCI-driven plasticity and compensations had caused to overlap were segregated. We conclude that effective robot rehabilitation training induces significant reorganization of trunk motor cortex and partially reverses some plastic changes that may be adaptive in non-stepping paraplegia after SCI.
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