Trial reportEndocrine2015
Predictive value of intratumoral heterogeneity of F-18 FDG uptake for characterization of thyroid nodules according to Bethesda categories of fine needle aspiration biopsy results.
Trial report in Endocrine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Application of radiomics and machine learning to thyroid diseases in nuclear medicine: a systematic review.Reviews in endocrine & metabolic disorders · 2024Pooled it
- The dilemma ofEndocrine · 2021Pooled it
- Focal Thyroid Incidentalomas onFrontiers in endocrinology · 2021Pooled it
- Quantitative classification and radiomics of [European journal of nuclear medicine and molecular imaging · 2022Trial
- Match Point: Nuclear Medicine Imaging for Recurrent Thyroid Cancer in TENIS Syndrome-Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- PET/CT May Assist in Avoiding Pointless Thyroidectomy in Indeterminate Thyroid Nodules: A Narrative Review.Cancers · 2023Review
- Radiomics Analysis of [Diagnostics (Basel, Switzerland) · 2022Review
- Comparison between Two Different Scanners for the Evaluation of the Role ofJournal of clinical medicine · 2022Article
- Radiomics analysis improvesEndocrine · 2022Article
- The Role of Metabolic Volumetric Parameters in Predicting Malignancy in Incidental Thyroid Nodules Detected inMolecular imaging and radionuclide therapy · 2021Article
- Characteristics of malignant thyroid lesions on [European journal of radiology open · 2021Article
- Differentiation of soft tissue and bone sarcomas from benign lesions utilizingBMC medical imaging · 2020Article
- Role of multi-modality functional imaging in differentiation between benign and malignant thyroidClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019Article
- Diagnostic Value of FDG PET-CT Quantitative Parameters and Deauville-Like 5 Point-Scale in Predicting Malignancy of Focal Thyroid Incidentaloma.Frontiers in medicine · 2019Article
- Radiomics in Oncological PET/CT: Clinical Applications.Nuclear medicine and molecular imaging · 2018Review
- [European journal of hybrid imaging · 2017Article
- A prospective cohort study to assess the role of FDG-PET in differentiating benign and malignant follicular neoplasms.Annals of medicine and surgery (2012) · 2016Article
- Single-cell approaches for molecular classification of endocrine tumors.Current opinion in oncology · 2016Review
- Diagnostic Value of Volume-Based Fluorine-18-Fluorodeoxyglucose PET/CT Parameters for Characterizing Thyroid Incidentaloma.Korean journal of radiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current study was aimed to investigate the clinical value of intratumoral heterogeneity of F-18 FDG uptake for characterization of thyroid nodule (TN) with inconclusive fine-needle aspiration biopsy (FNAB) results. The current study enrolled 200 patients who showed F-18 FDG incidentaloma and were performed FNAB. The intratumoral heterogeneity of F-18 FDG uptake was represented as the heterogeneity factor (HF), defined as the derivative (dV/dT) of a volume-threshold function for a primary tumor. The diagnostic and predictive values of HF and F-18 FDG PET/CT parameters were evaluated for characterization of inconclusive FNAB results. Among F-18 FDG PET/CT parameters, SUVmax, MTV, and TLG of malignant group were statistically higher than those of Bethesda category of suspicious malignant group. However, HF values were not statistically different between the groups of Bethesda categories (Kruskal-Wallis statistics, 9.924; p = 0.0774). In ROC analysis, when HF > 2.751 was used as cut-off value, the sensitivity and specificity for prediction of malignant TN were 100 % (95 % CI 69.2-100 %) and 60 % (95 % CI 42.1-76.1 %), respectively. The AUC was 0.826 (95 % CI 0.684-0.922) and standard error was 0.0648 (p < 0.0001). In conclusion, the intratumoral heterogeneity of F-18 FDG uptake represented by HF could be a predictor for characterization of TN with inconclusive FNAB results. Additional large population-based prospective studies are needed to validate the diagnostic utility of HF of F-18 FDG PET/CT.
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