ArticleInternational orthopaedics2015
Revision surgery after third generation autologous chondrocyte implantation in the knee.
Article in International orthopaedics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Increased risk of reoperation and failure to attain clinically relevant improvement following autologous chondrocyte implantation of the knee in female patients and individuals with previous surgeries: a time-to-event analysis based on the German cartilage registry (KnorpelRegister DGOU).Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- Low postoperative complication rate with high survival rate and good clinical outcome 9 years after autologous chondrocyte transplantation of the knee joint.Archives of orthopaedic and trauma surgery · 2023Article
- Effectiveness of an Accelerated Rehabilitation Protocol After Tibial Tubercle Osteotomy.Orthopaedic journal of sports medicine · 2022Article
- Excellent clinical and radiological outcomes after both open flake refixation and autologous chondrocyte implantation following acute patella dislocation and concomitant flake fractures.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Article
- Cell-based treatment options facilitate regeneration of cartilage, ligaments and meniscus in demanding conditions of the knee by a whole joint approach.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Review
- Does Flipping the Tubercle for Improved Cartilage Repair Exposure Increase the Risk for Arthrofibrosis?Cartilage · 2021Article
- Third-generation autologous chondrocyte implantation after failed bone marrow stimulation leads to inferior clinical results.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Article
- Autologous Chondrocyte Implantation "Segmental-Sandwich" Technique for Deep Osteochondral Defects in the Knee: Clinical Outcomes and Correlation With Magnetic Resonance Imaging Findings.Orthopaedic journal of sports medicine · 2019Article
- Optimization of TGF-β1-transduced chondrocytes for cartilage regeneration in a 3D printed knee joint model.PloS one · 2019Article
- Treatment of Failed Articular Cartilage Reconstructive Procedures of the Knee: A Systematic Review.Orthopaedic journal of sports medicine · 2018Review
- Review
- Matrix based autologous chondrocyte implantation in children and adolescents: a match paired analysis in a follow-up over three years post-operation.International orthopaedics · 2017Article
- Rapamycin-Induced Hypoxia Inducible Factor 2A Is Essential for Chondrogenic Differentiation of Amniotic Fluid Stem Cells.Stem cells translational medicine · 2016Article
- Cell-based chondral restoration.Current reviews in musculoskeletal medicine · 2015Article
Corrections and comments
- Erratum issuedErratum to: Revision surgery after third generation autologous chondrocyte implantation in the knee.2015 · Niethammer, Thomas [corrected to Niethammer, Thomas R]; Gülecyüz, Mehmet [corrected to Gülecyüz, Mehmet F]; Pietschmann, Matthias [corrected to Pietschmann, Matthias F]; Müller, Peter [corrected to Müller, Peter E]
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThird generation autologous chondrocyte implantation (ACI) is an established treatment for full thickness cartilage defects in the knee joint. However, little is known about cases when revision surgery is needed. The aim of the present study is to investigate the complication rates and the main reasons for revision surgery after third generation autologous chondrocyte implantation in the knee joint. It is of particular interest to examine in which cases revision surgery is needed and in which cases a "wait and see" strategy should be used.
methodsA total of 143 consecutive patients with 171 cartilage defects were included in this study with a minimum follow-up of two years. All defects were treated with third generation ACI (NOVACART®3D). Clinical evaluation was carried out after six months, followed by an annual evaluation using the International Knee Documentation Committee (IKDC) subjective score and the visual analogue scale (VAS) for rest and during activity. Revision surgery was documented.
resultsThe revision rate was 23.4 % (n = 36). The following major reasons for revision surgery were found in our study: symptomatic bone marrow edema (8.3 %, n = 3), arthrofibrosis (22.2 %, n = 8) and partial graft cartilage deficiency (47.2 %, n = 17). The following revision surgery was performed: retrograde drilling combined with Iloprost infusion therapy for bone marrow oedema (8.4 %, n = 3), arthroscopic arthrolysis of the suprapatellar recess (22.2 %, n = 8) and microfracturing/antegrade drilling (47.3 %, n = 17). Significant improvements of clinical scores after revision surgery were observed.
conclusionRevision surgery after third generation autologous chondrocyte implantation is common and is needed primarily in cases with arthrofibrosis, partial graft cartilage deficiency and symptomatic bone marrow oedema resulting in a significantly better clinical outcome.
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