ArticleThe Journal of veterinary medical science2015
Endostatin inhibits T-type Ca2+ channel current in guinea pig ventricular myocyte.
Article in The Journal of veterinary medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Endostatin in Renal and Cardiovascular Diseases.Kidney diseases (Basel, Switzerland) · 2021Review
- Endostatin is protective against monocrotaline-induced right heart disease through the inhibition of T-type Ca(2+) channel.Pflugers Archiv : European journal of physiology · 2016Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
Endostatin, a fragment of collagen XVIII, is known as an endogenous angiogenesis inhibitor, and its serum concentration increases in various cardiovascular diseases. T-type Ca(2+) channel, low voltage-activated Ca(2+) channel, is not expressed in adult ventricular myocytes. Re-expression of T-type Ca(2+) channels in cardiac myocytes is thought to be involved in the development of cardiac hypertrophy. We examined the effects of endostatin on T-type Ca(2+) channel current by whole-cell patch clamp technique in freshly isolated adult guinea pig ventricular myocytes, which exceptionally express T-type Ca(2+) channels. Although endostatin 300 ng/ml had no effect on L-type Ca(2+) current, it significantly inhibited T-type Ca(2+) current. These data indicate that endostatin can be an endogenous inhibitor of T-type Ca(2+) channels in the cardiac myocytes.
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