ArticleBiomechanics and modeling in mechanobiology2015
On the effects of leaflet microstructure and constitutive model on the closing behavior of the mitral valve.
Article in Biomechanics and modeling in mechanobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 68 citations in OpenAlex.
- Transcatheter measurement of mitral valve coaptation pressure: A proof-of-concept study using animal models.Bioengineering & translational medicine · 2026Article
- State-space formulations to understand the nonlinear viscoelastic mechanical behavior of tricuspid valve chordae tendineae.Applied mathematical modelling · 2026Article
- HETEROGENEOUS PERIDYNAMIC NEURAL OPERATORS: DISCOVER BIOTISSUE CONSTITUTIVE LAW AND MICROSTRUCTURE FROM DIGITAL IMAGE CORRELATION MEASUREMENTS.Foundations of data science (Springfield, Mo.) · 2025Article
- Simulated Effects of Acute Left Ventricular Myocardial Infarction on Mitral Regurgitation in an Ovine Model.Journal of biomechanical engineering · 2024Article
- Leaflet remodeling reduces tricuspid valve function in a computational model.Journal of the mechanical behavior of biomedical materials · 2024Article
- Impact of tricuspid annuloplasty device shape and size on valve mechanics-a computational study.JTCVS open · 2024Article
- A Computational Pipeline for Patient-Specific Prediction of the Postoperative Mitral Valve Functional State.Journal of biomechanical engineering · 2023Article
- The impact of thickness heterogeneity on soft tissue biomechanics: a novel measurement technique and a demonstration on heart valve tissue.Biomechanics and modeling in mechanobiology · 2023Article
- Functional mechanical behavior of the murine pulmonary heart valve.Scientific reports · 2023Article
- The effects of leaflet material properties on the simulated function of regurgitant mitral valves.Journal of the mechanical behavior of biomedical materials · 2023Article
- The Effects of leaflet material properties on the simulated function of regurgitant mitral valves.ArXiv · 2023Article
- A Physics-Guided Neural Operator Learning Approach to Model Biological Tissues From Digital Image Correlation Measurements.Journal of biomechanical engineering · 2022Article
- Ex vivo experimental characterizations for understanding the interrelationship between tissue mechanics and collagen microstructure of porcine mitral valve leaflets.Journal of the mechanical behavior of biomedical materials · 2022Article
- A Computational Framework for Atrioventricular Valve Modeling Using Open-Source Software.Journal of biomechanical engineering · 2022Article
- Viscoelastic modelling of the tricuspid valve chordae tendineae tissue.Applied mathematical modelling · 2022Article
- Pre-surgical Prediction of Ischemic Mitral Regurgitation Recurrence Using In Vivo Mitral Valve Leaflet Strains.Annals of biomedical engineering · 2021Article
- Adventures in Heart Valve Function A Personal Thank You to Dr. Ajit P. Yoganathan.Cardiovascular engineering and technology · 2021Article
- Isogeometric finite element-based simulation of the aortic heart valve: Integration of neural network structural material model and structural tensor fiber architecture representations.International journal for numerical methods in biomedical engineering · 2021Article
- Manifold learning based data-driven modeling for soft biological tissues.Journal of biomechanics · 2021Article
- A pilot in silico modeling-based study of the pathological effects on the biomechanical function of tricuspid valves.International journal for numerical methods in biomedical engineering · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Recent long-term studies showed an unsatisfactory recurrence rate of severe mitral regurgitation 3-5 years after surgical repair, suggesting that excessive tissue stresses and the resulting strain-induced tissue failure are potential etiological factors controlling the success of surgical repair for treating mitral valve (MV) diseases. We hypothesized that restoring normal MV tissue stresses in MV repair techniques would ultimately lead to improved repair durability through the restoration of MV normal homeostatic state. Therefore, we developed a micro- and macro- anatomically accurate MV finite element model by incorporating actual fiber microstructural architecture and a realistic structure-based constitutive model. We investigated MV closing behaviors, with extensive in vitro data used for validating the proposed model. Comparative and parametric studies were conducted to identify essential model fidelity and information for achieving desirable accuracy. More importantly, for the first time, the interrelationship between the local fiber ensemble behavior and the organ-level MV closing behavior was investigated using a computational simulation. These novel results indicated not only the appropriate parameter ranges, but also the importance of the microstructural tuning (i.e., straightening and re-orientation) of the collagen/elastin fiber networks at the macroscopic tissue level for facilitating the proper coaptation and natural functioning of the MV apparatus under physiological loading at the organ level. The proposed computational model would serve as a logical first step toward our long-term modeling goal-facilitating simulation-guided design of optimal surgical repair strategies for treating diseased MVs with significantly enhanced durability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.