ArticleProceedings of the National Academy of Sciences of the United States of America1989
Isolation and characterization of s-myc, a member of the rat myc gene family.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 64 citations in OpenAlex.
- Article
- An overview of MYC and its interactome.Cold Spring Harbor perspectives in medicine · 2014Review
- MYC-y mice: from tumour initiation to therapeutic targeting of endogenous MYC.Molecular oncology · 2013Review
- Article
- myc boxes, which are conserved in myc family proteins, are signals for protein degradation via the proteasome.Molecular and cellular biology · 1998Article
- A functional role for death proteases in s-Myc- and c-Myc-mediated apoptosis.Molecular and cellular biology · 1997Article
- The amplification of oligonucleotide themes in the evolution of the myc protooncogene family.Journal of molecular evolution · 1996Article
- Myc oncogenes: the enigmatic family.The Biochemical journal · 1996Review
- Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- A polymorphic variant of human c-Myc: Asn11-->Ser.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
- Reverse transcriptase: mediator of genomic plasticity.Virus genes · 1995Review
- Intracellular association of the protein product of the c-myc oncogene with the TATA-binding protein.Molecular and cellular biology · 1994Article
- Negative effects of wild-type p53 and s-Myc on cellular growth and tumorigenicity of glioma cells. Implication of the tumor suppressor genes for gene therapy.Journal of neuro-oncology · 1994Article
- Expression of the woodchuck N-myc2 retroposon in brain and in liver tumors is driven by a cryptic N-myc promoter.Molecular and cellular biology · 1992Article
- Testis-specific expression of the human MYCL2 gene.Nucleic acids research · 1991Article
- Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential.Molecular and cellular biology · 1991Article
- Point mutation of the neu gene in rat neural tumor RT4-AC cells: suppression of tumorigenicity by s-Myc.Japanese journal of cancer research : Gann · 1990Article
- An amino-terminal c-myc domain required for neoplastic transformation activates transcription.Molecular and cellular biology · 1990Article
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 9-kilobase-pair clone containing a myc-related gene that we have designated s-myc was isolated from a rat genomic library. The entire nucleotide sequence of the cloned DNA was determined, showing that the s-myc gene contains an open reading frame consisting of 1287 base pairs without introns. In vitro transcription-translation analysis of s-myc indicated that this gene produces a protein of approximately 50 kDa. The amino acid sequence predicted from the DNA sequence showed that the s-Myc protein is closely related to the murine N-Myc protein but lacks an acidic amino acid-rich sequence commonly present in the Myc-family proteins. Studies on transfection of s-myc into rat RT4-AC tumor cells revealed that the gene produces a polyadenylylated transcript of approximately 4.7 kilobases and that its high-level expression suppresses the tumor-igenicity of RT4-AC tumor cells in nude mice.
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