ArticleLasers in medical science2015
Performance analysis of the beam shaping method on optical auditory neural stimulation in vivo.
Article in Lasers in medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
- Optoacoustically induced auditory brainstem responses in the mouse model enhanced through an absorbing film.Journal of biomedical optics · 2021Article
- Influence of radiant exposure and repetition rate in infrared neural stimulation with near-infrared lasers.Lasers in medical science · 2019Article
- Optoacoustic effect is responsible for laser-induced cochlear responses.Scientific reports · 2016Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous research has shown that infrared neural stimulation (INS) could be an alternative approach to evoke auditory neural activities. The laser beam property of the fiber output is a considerable aspect of INS, and the corresponding effects on auditory responses in vivo deserve further discussions. The paper presents a beam-shaped infrared laser stimulation method of auditory nerves. Pulsed 980-nm fiber-coupled laser systems were used as the radiant sources. The gradient reflective index (GRIN) lens was added at the port of the optical fiber as a beam shaping structure. The laser spot sizes and properties between the beam-shaped output and the bare fiber output were preliminarily analyzed by a laser beam profiler. And further experiments in vivo with four deafened adult guinea pigs were conducted. Optically evoked auditory brainstem responses (OABRs) of the animal samples were recorded and compared under the two output configurations. The results show a decrease of the beam divergence compared to a bare output fiber, and the INS with a beam shaping design evokes above 13 % increase on OABR amplitudes than the bare fiber output, especially when enlarging the distance between the optical fiber and the nerve tissue. The beam shaping design can enhance the effect of INS for evoking auditory nerves, and it could be an optimized design in the future implementation of optical cochlear implants.
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Registered trials
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