ReviewChromosoma2016
Resolving complex chromosome structures during meiosis: versatile deployment of Smc5/6.
Review in Chromosoma, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- SMC5/6 Promotes Replication Fork Stability via Negative Regulation of the COP9 Signalosome.International journal of molecular sciences · 2024Article
- Article
- SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis.eLife · 2020Article
- Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to the COP9 signalosome.BMC molecular and cell biology · 2020Article
- A specialized condensin complex participates in somatic nuclear maturation inMolecular biology of the cell · 2019Article
- Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 during Replication Stress.Molecular and cellular biology · 2019Article
- Conditional Mutation of SMC5 in Mouse Embryonic Fibroblasts.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Ultrastructure and Dynamics of Synaptonemal Complex Components During Meiotic Pairing and Synapsis of Standard (A) and Accessory (B) Rye Chromosomes.Frontiers in plant science · 2019Article
- Article
- SMC5/6: Multifunctional Player in Replication.Genes · 2018Review
- Depletion of SMC5/6 sensitizes male germ cells to DNA damage.Molecular biology of the cell · 2018Article
- Chromatin Spread Preparations for the Analysis of Mouse Oocyte Progression from Prophase to Metaphase II.Journal of visualized experiments : JoVE · 2018Article
- SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes.Development (Cambridge, England) · 2017Article
- Non-SMC elements 1 and 3 are required for early embryo and seedling development in Arabidopsis.Journal of experimental botany · 2017Article
- Nesprin-2 Interacts with Condensin Component SMC2.International journal of cell biology · 2017Article
- Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress.International journal of molecular sciences · 2016Article
- Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease.The Journal of clinical investigation · 2016Article
- Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression.Journal of cell science · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The Smc5/6 complex, along with cohesin and condensin, is a member of the structural maintenance of chromosome (SMC) family, large ring-like protein complexes that are essential for chromatin structure and function. Thanks to numerous studies of the mitotic cell cycle, Smc5/6 has been implicated to have roles in homologous recombination, restart of stalled replication forks, maintenance of ribosomal DNA (rDNA) and heterochromatin, telomerase-independent telomere elongation, and regulation of chromosome topology. The nature of these functions implies that the Smc5/6 complex also contributes to the profound chromatin changes, including meiotic recombination, that characterize meiosis. Only recently, studies in diverse model organisms have focused on the potential meiotic roles of the Smc5/6 complex. Indeed, Smc5/6 appears to be essential for meiotic recombination. However, due to both the complexity of the process of meiosis and the versatility of the Smc5/6 complex, many additional meiotic functions have been described. In this review, we provide a clear overview of the multiple functions found so far for the Smc5/6 complex in meiosis. Additionally, we compare these meiotic functions with the known mitotic functions in an attempt to find a common denominator and thereby create clarity in the field of Smc5/6 research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.