ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2015
Sex differences in proximal and distal nephron function contribute to the mechanism of idiopathic hypercalcuria in calcium stone formers.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture.Nature communications · 2023Pooled it
- Steroid hormones and nephrolithiasis: regulation of urine components metabolism and inflammation.Biology of sex differences · 2026Review
- Association of demographic and biochemical factors with hypercalciuria among Meitei adults in Manipur, Northeast India: a cross-sectional study.Osong public health and research perspectives · 2025Article
- Paracellular Transport and Renal Tubule Calcium Handling: Emerging Roles in Kidney Stone Disease.Journal of the American Society of Nephrology : JASN · 2024Review
- Maternal family history of urolithiasis is associated with earlier age of onset of stone disease.World journal of urology · 2023Article
- Loss of Ecrg4 improves calcium oxalate nephropathy.PloS one · 2022Article
- Evidence for disordered acid-base handling in calcium stone-forming patients.American journal of physiology. Renal physiology · 2020Article
- Paracellular calcium transport in the proximal tubule and the formation of kidney stones.American journal of physiology. Renal physiology · 2019Review
- Randall's plaque in stone formers originates in ascending thin limbs.American journal of physiology. Renal physiology · 2018Article
- The influence of maternal and paternal history on stone composition and clinical course of calcium nephrolithiasis in subjects aged between 15 and 25.Urolithiasis · 2016Article
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Authors and funding
8 authors.
Funding
Abstract
Idiopathic hypercalciuria (IH) is a common familial trait among patients with calcium nephrolithiasis. Previously, we have demonstrated that hypercalciuria is primarily due to reduced renal proximal and distal tubule calcium reabsorption. Here, using measurements of the clearances of sodium, calcium, and endogenous lithium taken from the General Clinical Research Center, we test the hypothesis that patterns of segmental nephron tubule calcium reabsorption differ between the sexes in IH and normal subjects. When the sexes are compared, we reconfirm the reduced proximal and distal calcium reabsorption. In IH women, distal nephron calcium reabsorption is decreased compared to normal women. In IH men, proximal tubule calcium reabsorption falls significantly, with a more modest reduction in distal calcium reabsorption compared to normal men. Additionally, we demonstrate that male IH patients have lower systolic blood pressures than normal males. We conclude that women and men differ in the way they produce the hypercalciuria of IH, with females reducing distal reabsorption and males primarily reducing proximal tubule function.
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