Evidence map›Paper›PMID 25946948›Full record

Trial reportGlobal journal of health science2015

Lidocaine-Prilocaine Cream as Analgesia for IUD Insertion: A Prospective, Randomized, Controlled, Triple Blinded Study.

Samira Tavakolian, Mahbobeh Ahmadi Doulabi, Alireza Akbarzade Baghban, Alireza Mortazavi, Maryam Ghorbani

2 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Global journal of health science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
6.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03362905 phase4unknown statusnot on this mapstarted 2017, after this paper: background citation

Lidocaine for Pain Control During Intrauterine Device Insertion: A Randomized Clinical Trial

TypeinterventionalSponsorAin Shams UniversityRan2017 to 2019Enrolled123ConditionsIUD Insertion ComplicationArmsLidocaine topical
NCT07546370 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

The PLAN IUD Trial: The Effectiveness of Topical Prilocaine-Lidocaine Cream Plus Acetaminophen and Naproxen Compared to Lidocaine Injection Plus Acetaminophen and Naproxen to Manage Pain During IntraUterine Device Insertion: A Randomized Controlled Trial

TypeinterventionalSponsorMonakshi SawhneyRan2026 to 2027Enrolled66ConditionsPain During Intrauterine Device InsertionArmsPrilocaine, Lidocaine, Lidocaine HCl 1%
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Interventions for pain with intrauterine device insertion.The Cochrane database of systematic reviews · 2015
    Pooled it
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. New developments in intrauterine device use: focus on the US.Open access journal of contraception · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Samira Tavakolian
Mahbobeh Ahmadi Doulabi
Alireza Akbarzade Baghban
Alireza Mortazavi
Maryam Ghorbani. maryam_ghorbany89@yahoo.com.
Shahid Beheshti University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCopper IUD is a long term and reversible contraception which equals tubal ligation in terms of sterilization. One of the barriers to using this contraception method is the fear and the pain associated with its insertion. Eutectic mixture of local anesthetics (EMLA) 5% is a local anesthetic that contains 25 mg lidocaine and 25 mg of prilocaine per gram. Application of topical analgesic cream to the cervix for laser surgery, hysteroscopy and hysterosalpingography is known Aims: this study aimed to determine the effect of EMLA on IUD insertion pain.

methodsThis triple blind clinical trial was conducted on 92 women in a clinic in Hamedan in 2012. After applying the cream on the cervix, pain in three steps, after using Tenaculum, after inserting hystrometr and after inserting IUD and removing IUD insertion tube were assessed with visual analog scale and were compared in EMLA group and placebo group Statistical analysis used to determine and compare the pain of independent t tests, Mann-Whitney U test and repeated measures analysis of variance and chi-square tests to determine the homogeneity of variables and Fisher's exact test was used.

resultsInsertion hystrometr was determined as the most painful IUD insertion. The mean pain at step 2 (inserting hystrometr) was (3.11±2.53) in EMLA group, (5.23±2.31) in placebo group. EMLA cream significantly reduced the pain after using tenaculum (P<0.001), pain inserting Hystrometr (P< 0.001) and pain at IUD insertion and removing insertion tube (P< 0.001)

conclusionsTopical Application of EMLA 5% cream as a topical anesthetic on the cervix before insertion IUD reduced the pain during this procedure.

Indexed as

Intrauterine DevicesAdultAnalgesiaAnesthetics, CombinedDouble-Blind MethodFemaleHumansLidocaineLidocaine, Prilocaine Drug CombinationPainPrilocaineProspective StudiesTreatment OutcomeAnesthetics, CombinedLidocaineLidocaine, Prilocaine Drug CombinationPrilocaine

Identifiers

PMID25946948
PMCPMC4802174
OpenAlexW2152433511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.