ArticlePLoS genetics2015
Epistasis Is a Major Determinant of the Additive Genetic Variance in Mimulus guttatus.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Implications of dominance deviations for reproductive and morphological traits in the genetic management of the Pura Raza Española horse.Genetics, selection, evolution : GSE · 2026Article
- The effect of haplotype size on genomic selection accuracy and epistasis: An empirical study in rice.The plant genome · 2025Article
- Article
- Leveraging the genetic correlation between traits improves the detection of epistasis in genome-wide association studies.G3 (Bethesda, Md.) · 2023Article
- Higher-order epistasis shapes natural variation in germ stem cell niche activity.Nature communications · 2023Article
- Genotype-environment associations to reveal the molecular basis of environmental adaptation.The Plant cell · 2023Article
- Introduced populations of ragweed show as much evolutionary potential as native populations.Evolutionary applications · 2021Article
- The March of the Beetles: Epistatic Components Dominate Divergence in Dispersal Tendency in Tribolium castaneum.The Journal of heredity · 2020Article
- Mapping quantitative trait loci (QTLs) and estimating the epistasis controlling stem rot resistance in cultivated peanut (Arachis hypogaea).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- The Impact of Non-additive Effects on the Genetic Correlation Between Populations.G3 (Bethesda, Md.) · 2020Article
- Effectiveness of Genomic Selection by Response to Selection for Winter Wheat Variety Improvement.The plant genome · 2019Article
- Inferring the Nature of Missing Heritability in Human Traits Using Data from the GWAS Catalog.Genetics · 2019Article
- Analysis of Epistasis in Natural Traits Using Model Organisms.Trends in genetics : TIG · 2018Review
- SNP-skimming: A fast approach to map loci generating quantitative variation in natural populations.Molecular ecology resources · 2018Article
- Benefits of Dominance over Additive Models for the Estimation of Average Effects in the Presence of Dominance.G3 (Bethesda, Md.) · 2017Article
- The Fungal bZIP Transcription Factor AtfB Controls Virulence-Associated Processes in Aspergillus parasiticus.Toxins · 2017Article
- Naturally Segregating Variation atGenetics · 2017Article
- Article
- Detecting epistasis with the marginal epistasis test in genetic mapping studies of quantitative traits.PLoS genetics · 2017Article
- Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast.Nature genetics · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The influence of genetic interactions (epistasis) on the genetic variance of quantitative traits is a major unresolved problem relevant to medical, agricultural, and evolutionary genetics. The additive genetic component is typically a high proportion of the total genetic variance in quantitative traits, despite that underlying genes must interact to determine phenotype. This study estimates direct and interaction effects for 11 pairs of Quantitative Trait Loci (QTLs) affecting floral traits within a single population of Mimulus guttatus. With estimates of all 9 genotypes for each QTL pair, we are able to map from QTL effects to variance components as a function of population allele frequencies, and thus predict changes in variance components as allele frequencies change. This mapping requires an analytical framework that properly accounts for bias introduced by estimation errors. We find that even with abundant interactions between QTLs, most of the genetic variance is likely to be additive. However, the strong dependency of allelic average effects on genetic background implies that epistasis is a major determinant of the additive genetic variance, and thus, the population's ability to respond to selection.
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