ArticleAmyotrophic lateral sclerosis & frontotemporal degeneration2015
Comparison of diagnoses of amyotrophic lateral sclerosis by use of death certificates and hospital discharge data in the Danish population.
Article in Amyotrophic lateral sclerosis & frontotemporal degeneration, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Validity of Algorithms for Identification of Individuals Suffering from Chronic Noncancer Pain in Administrative Databases: A Systematic Review.Pain medicine (Malden, Mass.) · 2020Pooled it
- Accuracy of routinely-collected healthcare data for identifying motor neurone disease cases: A systematic review.PloS one · 2017Pooled it
- Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Have Distinct Prediagnostic Blood Biochemical Profiles.Annals of neurology · 2026Article
- Occupational lead exposure and amyotrophic lateral sclerosis survival in the Danish National Patient Registry.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2025Article
- Incidence and mortality of ALS: a 42-year population-based nationwide study.Journal of neurology · 2024Article
- Medication use and risk of amyotrophic lateral sclerosis: using machine learning for an exposome-wide screen of a large clinical database.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2024Article
- Registration of Amyotrophic Lateral Sclerosis: Validity in the Danish National Patient Registry.Clinical epidemiology · 2024Article
- Estimating mortality in rare diseases using a population-based registry, 2002 through 2019.Orphanet journal of rare diseases · 2023Article
- Exploring Relevant Time Windows in the Association Between PM2.5 Exposure and Amyotrophic Lateral Sclerosis: A Case-Control Study in Denmark.American journal of epidemiology · 2023Article
- Type 2 diabetes, obesity, and risk of amyotrophic lateral sclerosis: A population-based cohort study.Brain and behavior · 2023Article
- Long-term Traffic-related Air Pollutant Exposure and Amyotrophic Lateral Sclerosis Diagnosis in Denmark: A Bayesian Hierarchical Analysis.Epidemiology (Cambridge, Mass.) · 2022Article
- Analysis of incidence of motor neuron disease in England 1998-2019: use of three linked datasets.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2022Article
- Statin Medications and Amyotrophic Lateral Sclerosis Incidence and Mortality.American journal of epidemiology · 2022Article
- PMEnvironmental epidemiology (Philadelphia, Pa.) · 2022Article
- Pre-diagnostic plasma lipid levels and the risk of amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2021Article
- ALS in Danish Registries: Heritability and links to psychiatric and cardiovascular disorders.Neurology. Genetics · 2020Article
- A mixtures approach to solvent exposures and amyotrophic lateral sclerosis: a population-based study in Denmark.European journal of epidemiology · 2020Article
- The use of Logic regression in epidemiologic studies to investigate multiple binary exposures: an example of occupation history and amyotrophic lateral sclerosis.Epidemiologic methods · 2020Article
- Prediagnostic plasma branched-chain amino acids and the risk of amyotrophic lateral sclerosis.Neurology · 2019Article
- Population-based study of amyotrophic lateral sclerosis and occupational lead exposure in Denmark.Occupational and environmental medicine · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Because ALS is rare, large-scale studies are difficult. Hospital and death certificate data are valuable tools, but understanding of how well they capture cases is needed. We identified 3650 incident cases in the Danish National Patient Register (NPR) between 1982 and 2009, using ICD-8 (before 1994) or ICD-10 codes. Death certificates were obtained from the Danish Register of Causes of Death. We obtained medical records for 173 of the cases identified in the NPR and classified these according to the El Escorial criteria. We compared ALS identification from death certificates to hospital discharges, and both to medical records. Results showed that the sensitivity for use of death certificates was 84.2% (95% CI 82.9-85.5%) and was significantly higher for females, subjects younger than 77 years, and when coded with ICD-8. Using only the underlying cause of death resulted in significantly lower sensitivity. The estimated overall positive predictive value (PPV) was 82.0% (95% CI 80.0-83.8%). Sensitivity and PPV were similar compared with medical records. In conclusion, we found that use of hospital discharges and death certificates is highly reliable and, therefore, a valuable tool for ALS epidemiologic studies. The possible effects on findings of slight differences by age, gender, and ICD coding should be considered.
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