Evidence map›Paper›PMID 25946356›Full record

ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2015

Epidemiology of drug-resistant tuberculosis among children and adolescents in South Africa, 2005-2010.

B K Moore, E Anyalechi, M van der Walt, S Smith, L Erasmus, J Lancaster, S Morris, N Ndjeka, J Ershova, N Ismail and 2 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.

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  13. Survival of HIV-1 vertically infected children.Current opinion in HIV and AIDS · 2016
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

B K MooreCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
E AnyalechiCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
M van der WaltSouth African Medical Research Council, Cape Town, South Africa.
S SmithCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
L ErasmusNational Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.
J LancasterSouth African Medical Research Council, Cape Town, South Africa.
S MorrisCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
N NdjekaSouth Africa National Department of Health, Pretoria, South Africa.
J ErshovaCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
N IsmailNational Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, University of Pretoria, Pretoria, South Africa.
D BurtonCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
H MenziesCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
Centers for Disease Control and Prevention · USSouth African Medical Research Council · ZADepartment of Health · ZANational Health Laboratory Service · ZA

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

objectiveTo describe the demographic and clinical characteristics of children and adolescents diagnosed with resistance to any anti-tuberculosis drug (drug-resistant tuberculosis; DR-TB) in South Africa.

designWe retrospectively reviewed medical records of all children (<13 years) and adolescents (13 to <18 years) with DR-TB at specialty hospitals in four South African provinces from 2005 to 2010.

resultsDuring the review period, 774 children and adolescents (median age 11.3 years) were diagnosed with DR-TB at selected facilities. A high proportion of patients had a history of previous TB treatment (285/631; 45.2%), human immunodeficiency virus (HIV) infection (375/685; 54.7%), contact with a TB case (347/454; 76.4%), and smear-positive (443/729; 60.8%), cavitary (253/680, 38.7%) disease. Eighty-two per cent of patients with HIV infection received antiretroviral therapy. Of 626 patients diagnosed with multidrug-resistant TB (MDR-TB), 561 (89.6%) received a regimen consistent with national guidelines; the median length of treatment was 22 months (IQR 16-25). Among 400 patients with any DR-TB and a known outcome, 20.3% died during treatment.

conclusionPediatric DR-TB in these provinces is characterized by complex clinical features at diagnosis, with one in five children dying during treatment. History of previous treatment and contact with a TB patient indicate opportunities for earlier diagnosis and treatment to improve outcomes.

Indexed as

AdolescentAge DistributionAge FactorsAnti-HIV AgentsAntitubercular AgentsChildCoinfectionContact TracingFemaleHIV InfectionsHumansMaleMedical RecordsPredictive Value of TestsRetrospective StudiesRisk FactorsAnti-HIV AgentsAntitubercular Agents

Identifiers

PMID25946356
PMCPMC4886335
OpenAlexW2044987461

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.