ArticlePloS one2015
Temporal dynamics of stress-induced alternations of intrinsic amygdala connectivity and neuroendocrine levels.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- Stress and alcohol impact network states involved in emotional processing: relevance of comorbid AUD and psychiatric illnesses.Psychopharmacology · 2026Pooled it
- Emotion Processing in Schizophrenia: Insights From a Brain Imaging Study Comparing Patients, Siblings, and Healthy Controls.Human brain mapping · 2026Trial
- Effects of stress-related neuromodulators on amygdala and hippocampus resting state functional connectivity.Journal of psychopharmacology (Oxford, England) · 2024Trial
- Nx4 Modulated Resting-State Functional Connectivity Between Amygdala and Prefrontal Cortex in a Placebo-Controlled, Crossover Trial.Brain connectivity · 2022Trial
- Resting-state neural signatures of depressive symptoms in acute HIV.Journal of neurovirology · 2020Trial
- The validity of individual frontal alpha asymmetry EEG neurofeedback.Social cognitive and affective neuroscience · 2016Trial
- Neural signatures of human psychological resilience driven by acute stress.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Dynamic brain mechanisms supporting salient memories under cortisol.Science advances · 2025Article
- Neuroticism modulates functional connectivity of the midcingulate cortex during emotional conflict.Scientific reports · 2025Article
- Resting state EEG delta-beta amplitude-amplitude coupling: a neural predictor of cortisol response under stress.Cognitive neurodynamics · 2024Article
- Association of Lower Rostral Anterior Cingulate GABA+ and Dysregulated Cortisol Stress Response With Altered Functional Connectivity in Young Adults With Lifetime Depression: A Multimodal Imaging Investigation of Trait and State Effects.The American journal of psychiatry · 2024Article
- Exploring feasibility of fNIRS to assess delayed inhibition effect of prefrontal cortex for acute stress by acupuncture on GV20: a pilot study.Frontiers in human neuroscience · 2024Article
- Influence of chronic stress on network states governing valence processing: Potential relevance to the risk for psychiatric illnesses.Journal of neuroendocrinology · 2023Review
- Stress-induced Changes in Autonomic Reactivity Vary with Adolescent Violence Exposure and Resting-state Functional Connectivity.Neuroscience · 2023Article
- Stressor-Specific Sex Differences in Amygdala-Frontal Cortex Networks.Journal of clinical medicine · 2023Article
- Effects of neuromodulation on cognitive and emotional responses to psychosocial stressors in healthy humans.Neurobiology of stress · 2023Review
- Mild early-life stress exaggerates the impact of acute stress on corticolimbic resting-state functional connectivity.The European journal of neuroscience · 2022Article
- Inter-relationships between changes in stress, mindfulness, and dynamic functional connectivity in response to a social stressor.Scientific reports · 2022Article
- Reductions in rostral anterior cingulate GABA are associated with stress circuitry in females with major depression: a multimodal imaging investigation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- The functional connectome predicts feeling of stress on regular days and during the COVID-19 pandemic.Neurobiology of stress · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress-induced changes in functional brain connectivity have been linked to the etiology of stress-related disorders. Resting state functional connectivity (rsFC) is especially informative in characterizing the temporal trajectory of glucocorticoids during stress adaptation. Using the imaging Maastricht Acute Stress Test (iMAST), we induced acute stress in 39 healthy volunteers and monitored the neuroendocrine stress levels during three runs of resting state functional magnetic resonance imaging (rs-fMRI): before (run 1), immediately following (run 2), and 30 min after acute stress (run 3). The iMAST resulted in strong increases in cortisol levels. Whole-brain analysis revealed that acute stress (run 2 - 1) was characterized by changes in connectivity of the amygdala with the ventrolateral prefrontal cortex (vlPFC), ventral posterior cingulate cortex (PCC), cuneus, parahippocampal gyrus, and culmen. Additionally, cortisol responders were characterized by enhanced amygdala - medial prefrontal cortex (mPFC) connectivity. Stress recovery (run 3 - 2) was characterized by altered amygdala connectivity with the dorsolateral prefrontal cortex (dlPFC), ventral and dorsal anterior cingulate cortex (ACC), anterior hippocampal complex, cuneus, and presupplementary motor area (preSMA). Opposite to non-responders, cortisol responders were characterized by enhanced amygdala connectivity with the anterior hippocampal complex and parahippocampal gyrus, and reduced connectivity with left dlPFC, dACC, and culmen during early recovery. Acute stress responding and recovery are thus associated with changes in the functional connectivity of the amygdala network. Our findings show that these changes may be regulated via stress-induced neuroendocrine levels. Defining stress-induced neuronal network changes is pertinent to developing treatments that target abnormal neuronal activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.