Evidence map›Paper›PMID 25946107›Full record

ArticleeLife2015

What is the point of pseudokinases?

Saravanan Raju, Andrey S Shaw

Abstract readComment
In one paragraph

Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Moonlighting Proteins Shine New Light on Molecular Signaling Niches.International journal of molecular sciences · 2021
    Review
  6. Dynamic regulatory features of the protein tyrosine kinases.Biochemical Society transactions · 2019
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Saravanan RajuDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, United States.
Andrey S ShawDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, United States shaw@pathology.wustl.edu.

Funding

PRINCIPLES IN PULMONARY RESEARCHT32HL007317 · NHLBI · WASHINGTON UNIVERSITY · PI Steven Brody, Michael J Holtzman · 1985 to 2026
$16.1M
NHLBI NIH HHS T32 HL007317
6 · The paper itself

Abstract

The interaction between an active kinase and an 'inactive' pseudokinase provides clues about how these enzymes were regulated in the past, and how this regulation has evolved.

Indexed as

AmeloblastsAnimalsCasein Kinase IDental Enamel ProteinsExtracellular Matrix ProteinsFemaleHumansCasein Kinase IDental Enamel ProteinsExtracellular Matrix Proteinsbiochemistryextracellular protein phosphorylationhumankinase complexmousepseudokinasesecretory pathway phosphorylationtooth enamel formation

Identifiers

PMID25946107
PMCPMC4421857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.