ArticlePloS one2015
The Regulation of Lipid Deposition by Insulin in Goose Liver Cells Is Mediated by the PI3K-AKT-mTOR Signaling Pathway.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
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- Genetic regulation of insulin resistance surrogate index (TyG) and susceptibility to common diseases based on phenome-wide association study.Molecular and cellular biochemistry · 2026Article
- Functional Equivalence of Insulin and IGF-1 in the In Vitro Culture of Chicken Primordial Germ Cells.Genes · 2025Article
- Changes in the Expression of Some Genes With Metabolic, VLDL and Antioxidative Effects After the Addition of Essential Oil Mixture to Drinking Water in the Liver of Domestic Geese (Anser anser Domesticus).Veterinary medicine and science · 2025Article
- A Review Unveiling the Ferroptosis-Regulated Cell Signalling Pathways in Breast Cancer to Elucidate Potent Targets for Cancer Management.Current pharmaceutical design · 2025Review
- Development of hepatic steatosis in male and female mule ducks after respective force-feeding programs.Frontiers in physiology · 2024Article
- Effects of essential oil mixtures on expression of genes involved in lipogenesis and fatty acid oxidation in geese (Anser anser).Tropical animal health and production · 2023Article
- Liver Transcriptome Profiling Identifies Key Genes Related to Lipid Metabolism in Yili Geese.Animals : an open access journal from MDPI · 2023Article
- Effect of Dietary Manganese on the Growth Performance, Lipid Metabolism, and Antioxidant Capacity in the Post-Larval Coho Salmon (Animals : an open access journal from MDPI · 2023Article
- Betaine Promotes Fat Accumulation and Reduces Injury in Landes Goose Hepatocytes by Regulating Multiple Lipid Metabolism Pathways.Animals : an open access journal from MDPI · 2022Article
- Regulation of the cecal microbiota community and the fatty liver deposition by the addition of brewers' spent grain to feed of Landes geese.Frontiers in microbiology · 2022Article
- Transcriptional analysis of microRNAs related to unsaturated fatty acid synthesis by interfering bovine adipocyte ACSL1 gene.Frontiers in genetics · 2022Article
- Liver fat metabolism of broilers regulated byFrontiers in microbiology · 2022Article
- Effect of docosahexaenoic acid plus insulin on atherosclerotic human endothelial cells.Journal of inflammation (London, England) · 2021Article
- ROS and Lipid Droplet accumulation induced by high glucose exposure in healthy colon and Colorectal Cancer Stem Cells.Genes & diseases · 2020Article
- Vitamin C inhibits lipid deposition through GSK-3β/mTOR signaling in the liver of zebrafish.Fish physiology and biochemistry · 2020Article
- Pressure suppresses hepatocellular glycogen synthesis through activating the p53/Pten pathway.Molecular medicine reports · 2019Article
- Association analysis between feed efficiency and expression of key genes of the avTOR signaling pathway in meat-type ducks.Molecular biology reports · 2019Article
- Lipidomic Profiling Reveals Disruption of Lipid Metabolism in Valproic Acid-Induced Hepatotoxicity.Frontiers in pharmacology · 2019Article
- Inhibition of protein arginine methyltransferase 5 enhances hepatic mitochondrial biogenesis.The Journal of biological chemistry · 2018Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe previously showed that the fatty liver formations observed in overfed geese are accompanied by the activation of the PI3K-Akt-mTOR pathway and an increase in plasma insulin concentrations. Recent studies have suggested a crucial role for the PI3K-Akt-mTOR pathway in regulating lipid metabolism; therefore, we hypothesized that insulin affects goose hepatocellular lipid metabolism through the PI3K-Akt-mTOR signaling pathway.
methodsGoose primary hepatocytes were isolated and treated with serum-free media supplemented with PI3K-Akt-mTOR pathway inhibitors (LY294002, rapamycin, and NVP-BEZ235, respectively) and 50 or 150 nmol/L insulin.
resultsInsulin induced strong effects on lipid accumulation as well as the mRNA and protein levels of genes involved in lipogenesis, fatty acid oxidation, and VLDL-TG assembly and secretion in primary goose hepatocytes. The stimulatory effect of insulin on lipogenesis was significantly decreased by treatment with PI3K-Akt-mTOR inhibitors. These inhibitors also rescued the insulin-induced down-regulation of fatty acid oxidation and VLDL-TG assembly and secretion.
conclusionThese findings suggest that the stimulatory effect of insulin on lipid deposition is mediated by PI3K-Akt-mTOR regulation of lipogenesis, fatty acid oxidation, and VLDL-TG assembly and secretion in goose hepatocytes.
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