Evidence map›Paper›PMID 25945737›Full record

ArticleNature2015

An alternative pluripotent state confers interspecies chimaeric competency.

Jun Wu, Daiji Okamura, Mo Li, Keiichiro Suzuki, Chongyuan Luo, Li Ma, Yupeng He, Zhongwei Li, Chris Benner, Isao Tamura and 17 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed
17.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 248 citations in OpenAlex.

  1. The making of cells and organs in xenogeneic animal bioreactor.Signal transduction and targeted therapy · 2026
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69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 7 institutions in 3 countries.

Jun WuThe Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, California 92037, USA.
Daiji OkamuraThe Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, California 92037, USA.
Mo LiThe Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, California 92037, USA.
Keiichiro SuzukiThe Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, California 92037, USA.
Chongyuan Luo1] Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California 92037, USA [2] The Salk Institute for Biological Studies, Genomic Analysis Laboratory, La Jolla, California 92037, USA.
Li MaThe Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, California 92037, USA.
Yupeng HeThe Salk Institute for Biological Studies, Genomic Analysis Laboratory, La Jolla, California 92037, USA.
Zhongwei LiThe Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, California 92037, USA.
Chris BennerThe Salk Institute for Biological Studies, Integrated Genomics, La Jolla, California 92037, USA.
Isao TamuraThe Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, California 92037, USA.
Marie N KrauseThe Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, California 92037, USA.
Joseph R NeryThe Salk Institute for Biological Studies, Genomic Analysis Laboratory, La Jolla, California 92037, USA.
Tingting DuLudwig Institute for Cancer Research, University of California, San Diego School of Medicine, Department of Cellular and Molecular Medicine, 9500 Gilman Drive, La Jolla, California 92093-0653, USA.
Zhuzhu ZhangThe Salk Institute for Biological Studies, Genomic Analysis Laboratory, La Jolla, California 92037, USA.
Tomoaki HishidaThe Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, California 92037, USA.
Yuta Takahashi1] The Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, California 92037, USA [2] Life Science Center, Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8577, Japan.
Emi AizawaThe Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, California 92037, USA.
Na Young KimThe Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, California 92037, USA.
Jeronimo LajaraGrado en Medicina, Universidad Católica, San Antonio de Murcia, Campus de los Jerónimos, 135, Guadalupe 30107, Spain.
Pedro Guillen1] Grado en Medicina, Universidad Católica, San Antonio de Murcia, Campus de los Jerónimos, 135, Guadalupe 30107, Spain [2] Fundacion Pedro Guillen, Clínica Cemtro, Avenida Ventisquero de la Condesa, 42, 28035 Madrid, Spain.
Josep M CampistolHospital Clinic of Barcelona, Carrer Villarroel, 170, 08036 Barcelona, Spain.
Concepcion Rodriguez EstebanThe Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, California 92037, USA.
Pablo J RossUniversity of California, Davis, Davis, California 95616, USA.
Alan SaghatelianThe Salk Institute for Biological Studies, Peptide Biology Laboratory, La Jolla, California 92037, USA.
Bing RenLudwig Institute for Cancer Research, University of California, San Diego School of Medicine, Department of Cellular and Molecular Medicine, 9500 Gilman Drive, La Jolla, California 92093-0653, USA.
Joseph R Ecker1] Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California 92037, USA [2] The Salk Institute for Biological Studies, Genomic Analysis Laboratory, La Jolla, California 92037, USA.
Juan Carlos Izpisua BelmonteThe Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, California 92037, USA.
Salk Institute for Biological Studies · USUniversidad Católica San Antonio de Murcia · ESUniversity of California, San Diego · USHospital Clínic de Barcelona · ESHoward Hughes Medical Institute · USUniversity of California, Davis · USUniversity of Tsukuba · JP

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

Pluripotency, the ability to generate any cell type of the body, is an evanescent attribute of embryonic cells. Transitory pluripotent cells can be captured at different time points during embryogenesis and maintained as embryonic stem cells or epiblast stem cells in culture. Since ontogenesis is a dynamic process in both space and time, it seems counterintuitive that these two temporal states represent the full spectrum of organismal pluripotency. Here we show that by modulating culture parameters, a stem-cell type with unique spatial characteristics and distinct molecular and functional features, designated as region-selective pluripotent stem cells (rsPSCs), can be efficiently obtained from mouse embryos and primate pluripotent stem cells, including humans. The ease of culturing and editing the genome of human rsPSCs offers advantages for regenerative medicine applications. The unique ability of human rsPSCs to generate post-implantation interspecies chimaeric embryos may facilitate our understanding of early human development and evolution.

Indexed as

ChimeraAnimalsCell Culture TechniquesCell LineEmbryonic Stem CellsFemaleGerm LayersHumansInduced Pluripotent Stem CellsMaleMicePan troglodytesPluripotent Stem CellsRegenerative MedicineSpecies Specificity

Identifiers

PMID25945737
PMCPMC5278765
OpenAlexW1828975488

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.