ArticleDevelopmental psychobiology2015
Pregnancy distress gets under fetal skin: Maternal ambulatory assessment & sex differences in prenatal development.
Article in Developmental psychobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04363177 (Mental Health of Urban Mothers), which is not on this map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mental Health of Urban Mothers (MUM) Study: A Multi-center Randomized Controlled Trial
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Readdressing the Ongoing Challenge of Missing Data in Youth Ecological Momentary Assessment Studies: Meta-Analysis Update.Journal of medical Internet research · 2025Pooled it
- Participant Compliance With Ecological Momentary Assessment in Movement Behavior Research Among Adolescents and Emerging Adults: Systematic Review.JMIR mHealth and uHealth · 2025Pooled it
- Prenatal maternal distress and fetal heart rate: Examining sex-specific sensitivity.Journal of affective disorders · 2026Article
- Maternal high BMI: Sex-dimorphic alterations in maternal and offspring stress indices.Psychoneuroendocrinology · 2025Article
- Exploring emotions beyond the laboratory: A review of emotional and physiological ecological momentary assessment methods in children and youth.Psychophysiology · 2024Review
- Natural Disasters as a Maternal Prenatal Stressor and Children's Neurodevelopment: A Systematic Review.Behavioral sciences (Basel, Switzerland) · 2024Review
- Maternal prenatal immune activation associated with brain tissue microstructure and metabolite concentrations in newborn infants.Brain, behavior, and immunity · 2024Article
- Mapping Early Brain-Body Interactions: Associations of Fetal Heart Rate Variation with Newborn Brainstem, Hypothalamic, and Dorsal Anterior Cingulate Cortex Functional Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Impact of maternal emotional state during pregnancy on fetal heart rate variability.Comprehensive psychoneuroendocrinology · 2023Article
- Maternal adverse childhood experiences impact fetal adrenal volume in a sex-specific manner.Biology of sex differences · 2023Article
- Third Trimester Fetuses Demonstrate Priming, a Form of Implicit Memory, In Utero.Children (Basel, Switzerland) · 2022Article
- Maternal caregiving ameliorates the consequences of prenatal maternal psychological distress on child development.Development and psychopathology · 2022Article
- Estrogen receptors mediate the antidepressant effects of aerobic exercise: A possible new mechanism.Frontiers in aging neuroscience · 2022Article
- Prenatal origins of temperament: Fetal cardiac development & infant surgency, negative affectivity, and regulation/orienting.Infant behavior & development · 2021Article
- Interactions of genetic variants and prenatal stress in relation to the risk for recurrent respiratory infections in children.Scientific reports · 2021Article
- Maternal psychosocial functioning, obstetric health history, and newborn telomere length.Psychoneuroendocrinology · 2021Article
- Article
- Prenatal maternal psychological distress and fetal developmental trajectories: associations with infant temperament.Development and psychopathology · 2020Article
- Mental health of Urban Mothers (MUM) study: a multicentre randomised controlled trial, study protocol.BMJ open · 2020Article
- Evaluation of maternal inflammation as a marker of future offspring ADHD symptoms: A prospective investigation.Brain, behavior, and immunity · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Prenatal maternal distress is associated with an at-risk developmental profile, yet there is little fetal evidence of this putative in utero process. Moreover, the biological transmission for these maternal effects remains uncertain. In a study of n = 125 pregnant adolescents (ages 14-19), ambulatory assessments of daily negative mood (anger, frustration, irritation, stress), physical activity, blood pressure, heart rate (every 30 min over 24 hr), and salivary cortisol (six samples) were collected at 13-16, 24-27, 34-37 gestational weeks. Corticotropin-releasing hormone, C-reactive protein, and interleukin 6 from blood draws and 20 min assessments of fetal heart rate (FHR) and movement were acquired at the latter two sessions. On average, fetuses showed development in the expected direction (decrease in FHR, increase in SD of FHR and in the correlation of movement and FHR ("coupling")). Maternal distress characteristics were associated with variations in the level and trajectory of fetal measures, and results often differed by sex. For males, greater maternal 1st and 2nd session negative mood and 2nd session physical activity were associated with lower overall FHR (p < .01), while 1st session cortisol was associated with a smaller increase in coupling (p < .01), and overall higher levels (p = .05)-findings suggesting accelerated development. For females, negative mood, cortisol, and diastolic blood pressure were associated with indications of relatively less advanced and accelerated outcomes. There were no associations between negative mood and biological variables. These data indicate that maternal psychobiological status influences fetal development, with females possibly more variously responsive to different exposures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.