SynthesisPublic health nutrition2016
Garlic consumption and colorectal cancer risk in man: a systematic review and meta-analysis.
Synthesis in Public health nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Role of Diet in Colorectal Cancer Incidence: Umbrella Review of Meta-analyses of Prospective Observational Studies.JAMA network open · 2021Pooled it
- Allium Vegetables, Garlic Supplements, and Risk of Cancer: A Systematic Review and Meta-Analysis.Frontiers in nutrition · 2021Pooled it
- Therapeutic potential of garlic-derived exosome like nanovesicles: challenge and opportunity.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Review
- Current State of Knowledge of the Anticancer Properties of Polyphenolic Compounds from Garlic (Molecules (Basel, Switzerland) · 2026Review
- Dietary Manipulation on Gut Microbiome in Patients with Diabetes and Colorectal cancer.Current nutrition reports · 2025Review
- Garlic consumption and colorectal cancer risk in US adults: a large prospective cohort study.Frontiers in nutrition · 2023Article
- Association and mechanism of garlic consumption with gastrointestinal cancer risk: A systematic review and meta-analysis.Oncology letters · 2022Review
- Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment.Frontiers in pharmacology · 2022Review
- Effects of garlic intake on cancer: a systematic review of randomized clinical trials and cohort studies.Nutrition research and practice · 2021Article
- Phytochemically rich dietary components and the risk of colorectal cancer: A systematic review and meta-analysis of observational studies.World journal of clinical oncology · 2021Article
- Allium vegetable consumption and health: An umbrella review of meta-analyses of multiple health outcomes.Food science & nutrition · 2019Review
- Dietary and the Risk of Sporadic Colorectal Cancer in China: A Case-control Study.Iranian journal of public health · 2018Article
- A novel therapeutic anticancer property of raw garlic extract via injection but not ingestion.Cell death discovery · 2018Article
- Colors of vegetables and fruits and the risks of colorectal cancer.World journal of gastroenterology · 2017Article
- Effect of garlic supplement in the management of type 2 diabetes mellitus (T2DM): a meta-analysis of randomized controlled trials.Food & nutrition research · 2017Article
- Spices for Prevention and Treatment of Cancers.Nutrients · 2016Review
- Food Processing and the Mediterranean Diet.Nutrients · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveColorectal cancer shows large incidence variations worldwide that have been attributed to different dietary factors. We conducted a meta-analysis on the relationship between garlic consumption and colorectal cancer risk.
designWe systematically reviewed publications obtained by searching ISI Web of Knowledge, MEDLINE and EMBASE literature databases. We extracted the risk estimate of the highest and the lowest reported categories of intake from each study and conducted meta-analysis using a random-effects model.
resultsThe pooled analysis of all fourteen studies, seven cohort and seven case-control, indicated that garlic consumption was not associated with colorectal cancer risk (OR=0·93; 95 % CI 0·82, 1·06, P=0·281; I 2=83·6 %, P≤0·001). Separate analyses on the basis of cancer sites and sex also revealed no statistically significant effects on cancer risk. However, when separately analysed on the basis of study type, we found that garlic was associated with an approximately 37 % reduction in colorectal cancer risk in the case-control studies (combined risk estimate=0·63, 95 % CI 0·48, 0·82, P=0·001; I 2=75·6 %, P≤0·001).
conclusionsOur results suggest that consumption of garlic is not associated with a reduced colorectal cancer risk. Further investigations are necessary to clarify the discrepancy between results obtained from different types of epidemiological studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.