ArticleJournal of diabetes research2015
A new approach to define and diagnose cardiometabolic disorder in children.
Article in Journal of diabetes research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Promoting health-related cardiorespiratory fitness in physical education: A systematic review.PloS one · 2020Pooled it
- Effect of a 1-year physical activity intervention on cardiovascular health in long-term childhood cancer survivors-a randomised controlled trial (SURfit).British journal of cancer · 2023Trial
- Body composition, physical fitness and cardiovascular risk factors in 9-year-old children.Scientific reports · 2022Trial
- Mediation of obesity-related variables in the association between physical fitness and cardiometabolic risk in children and adolescents: a systematic review and meta-analysis.BMJ open sport & exercise medicine · 2025Article
- Adiponectin concentration and cardiometabolic risk factors: the moderator role of cardiorespiratory fitness in adolescents.European journal of pediatrics · 2024Article
- Screen time, sleep duration, leisure physical activity, obesity, and cardiometabolic risk in children and adolescents: a cross-lagged 2-year study.BMC cardiovascular disorders · 2024Observational
- Isotemporal substitution of accelerometer-derived sedentary behavior and physical activity on physical fitness in young children.Scientific reports · 2024Article
- Examining the mediating role of muscle quantity in adolescents: associations with adiposity, cardiorespiratory fitness, muscular fitness, and cardiometabolic risk factors.Scientific reports · 2024Article
- Article
- Clustered Cardiometabolic Risk and the "Fat but Fit Paradox" in Adolescents: Cross-Sectional Study.Nutrients · 2024Article
- Unsupervised identification of cardiometabolic profiles among adolescents: findings from the PARIS birth cohort study.European journal of pediatrics · 2024Article
- Cardiorespiratory Fitness and Body Mass Index as Predictors of Metabolic Syndrome in Schoolchildren (PACH Study).Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Body Mass Index, Physical Activity, Cardiorespiratory Endurance and Quality of Life among Children with Physical Disabilities.Children (Basel, Switzerland) · 2023Article
- The stability of cardiometabolic risk factors clustering in children and adolescents: a 2-year longitudinal study.Journal of diabetes and metabolic disorders · 2023Article
- Metabolic risk is associated with sociodemographic characteristics in adolescents from both rural and urban regions from southern Brazil.BMC pediatrics · 2022Article
- Clustering of cardiometabolic risk factors and the continuous cardiometabolic risk score in children from Southern Brazil: a cross-sectional study.Journal of diabetes and metabolic disorders · 2021Article
- Longitudinal assessment between lifestyle-related risk factors and a composite cardiovascular disease (CVD) risk index among adolescents in Malaysia.Scientific reports · 2021Observational
- Biological and socioeconomic factors as moderator in relationship between leisure-time physical activity and cardiometabolic risk in adolescents from southern Brazil.Environmental health and preventive medicine · 2021Article
- Mediation role of cardiorespiratory fitness on the association between fatness and cardiometabolic risk in European adolescents: The HELENA study.Journal of sport and health science · 2021Article
- Physical Activity, Screen-Based Sedentary Behavior and Physical Fitness in Chinese Adolescents: A Cross-Sectional Study.Frontiers in pediatrics · 2021Article
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 7 countries.
Funding
Abstract
The aim of the study was to test the performance of a new definition of metabolic syndrome (MetS), which better describes metabolic dysfunction in children. Methods. 15,794 youths aged 6-18 years participated. Mean z-score for CVD risk factors was calculated. Sensitivity analyses were performed to evaluate which parameters best described the metabolic dysfunction by analysing the score against independent variables not included in the score. Results. More youth had clustering of CVD risk factors (>6.2%) compared to the number selected by existing MetS definitions (International Diabetes Federation (IDF) < 1%). Waist circumference and BMI were interchangeable, but using insulin resistance homeostasis model assessment (HOMA) instead of fasting glucose increased the score. The continuous MetS score was increased when cardiorespiratory fitness (CRF) and leptin were included. A mean z-score of 0.40-0.85 indicated borderline and above 0.85 indicated clustering of risk factors. A noninvasive risk score based on adiposity and CRF showed sensitivity and specificity of 0.85 and an area under the curve of 0.92 against IDF definition of MetS. Conclusions. Diagnosis for MetS in youth can be improved by using continuous variables for risk factors and by including CRF and leptin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.