Evidence map›Paper›PMID 25945260›Full record

Trial reportNeural plasticity2015

Neuroplastic effects of combined computerized physical and cognitive training in elderly individuals at risk for dementia: an eLORETA controlled study on resting states.

Charis Styliadis, Panagiotis Kartsidis, Evangelos Paraskevopoulos, Andreas A Ioannides, Panagiotis D Bamidis

4 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neural plasticity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 57 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 13 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02313935 nacompletednot on this map

Effects of Cognitive and/or Physical Exercises Blended by Computer Games in Elderly: The LLM Project Neuroscientific Investigations in Thessaloniki, Greece by the LLM Team at the Aristotle University of Thessaloniki

TypeinterventionalSponsorAristotle University Of ThessalonikiRan2010 to 2013Enrolled581ConditionsMild Cognitive Impairment, So Stated, Mild Dementia, HealthyArmsLLM, FFA, Brain Fitness, VideoGrade
NCT04390321 nacompletednot on this mapstarted 2017, after this paper: background citation

Application of Cognitive and Physical Training (LLM Care) and Related Affective Computing Systems on Persons With Special Needs (Cognitive Disorders)

TypeinterventionalSponsorAristotle University Of ThessalonikiRan2017 to 2022Enrolled46ConditionsDown SyndromeArmsLLMcare
NCT04426903 nacompletednot on this mapstarted 2017, after this paper: background citation

Application of Cognitive and Physical Training (LLM Care) and Related Affective Computing Systems on People With Parkinson's Disease (Movement Disorders)

TypeinterventionalSponsorAristotle University Of ThessalonikiRan2017 to 2018Enrolled23ConditionsParkinson DiseaseArmswebFitForAll, BrainHQ
NCT04806568 narecruitingnot on this mapstarted 2020, after this paper: background citation

Cognitive Decline Prognosis in Multiple Sclerosis: Effectiveness of a Computerized Cognitive Training Treatment on Cortical Reorganization

TypeinterventionalSponsorAristotle University Of ThessalonikiRan2020 to 2025Enrolled180ConditionsMultiple Sclerosis, Cognitive DeclineArmsCognitive Training, Monitoring of daily activity
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 13 syntheses or guidelines pooled it, 116 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Charis StyliadisLab of Medical Physics, Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, P.O. Box 376, 54124 Thessaloniki, Greece.ORCID 0000-0001-7383-2439
Panagiotis KartsidisLab of Medical Physics, Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, P.O. Box 376, 54124 Thessaloniki, Greece.
Evangelos ParaskevopoulosLab of Medical Physics, Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, P.O. Box 376, 54124 Thessaloniki, Greece.ORCID 0000-0003-4063-4182
Andreas A IoannidesLaboratory for Human Brain Dynamics, AAI Scientific Cultural Services Ltd., Office 501, Galaxias Building Block A, 33 Arch. Makarios III Avenue, 1065 Nicosia, Cyprus.
Panagiotis D BamidisLab of Medical Physics, Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, P.O. Box 376, 54124 Thessaloniki, Greece.
Aristotle University of Thessaloniki · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study investigates whether a combined cognitive and physical training may induce changes in the cortical activity as measured via electroencephalogram (EEG) and whether this change may index a deceleration of pathological processes of brain aging. Seventy seniors meeting the clinical criteria of mild cognitive impairment (MCI) were equally divided into 5 groups: 3 experimental groups engaged in eight-week cognitive and/or physical training and 2 control groups: active and passive. A 5-minute long resting state EEG was measured before and after the intervention. Cortical EEG sources were modelled by exact low resolution brain electromagnetic tomography (eLORETA). Cognitive function was assessed before and after intervention using a battery of neuropsychological tests including the minimental state examination (MMSE). A significant training effect was identified only after the combined training scheme: a decrease in the post- compared to pre-training activity of precuneus/posterior cingulate cortex in delta, theta, and beta bands. This effect was correlated to improvements in cognitive capacity as evaluated by MMSE scores. Our results indicate that combined physical and cognitive training shows indices of a positive neuroplastic effect in MCI patients and that EEG may serve as a potential index of gains versus cognitive declines and neurodegeneration. This trial is registered with ClinicalTrials.gov Identifier NCT02313935.

Indexed as

Cognitive Behavioral TherapyExercise TherapyNeuronal PlasticityAgedCerebral CortexCognitive DysfunctionCombined Modality TherapyDementiaElectroencephalographyFemaleHumansMaleNeuropsychological TestsRisk FactorsTreatment Outcome

Identifiers

PMID25945260
PMCPMC4405298
OpenAlexW2094850853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.