ArticleBiomicrofluidics2015
Microfluidic-based speckle analysis for sensitive measurement of erythrocyte aggregation: A comparison of four methods for detection of elevated erythrocyte aggregation in diabetic rat blood.
Article in Biomicrofluidics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 52 citations in OpenAlex.
- Continuous Measurement of Spatially Resolved Red Blood Cell Aggregation Using Multiple Side-Branch Channels.Biosensors · 2026Article
- A Pulsatile Flow-Modulation Microfluidic Sensor for Simultaneous Monitoring of Red Blood Cell Aggregation and Viscosity-Sensitive Time Constant.Sensors (Basel, Switzerland) · 2026Article
- Significance of Hemorheological Tests During Mycoplasma Pulmonis Infection in Laboratory Rats.Animals : an open access journal from MDPI · 2025Article
- Assessment of Red Blood Cell Aggregation in Preeclampsia by Microfluidic Image Flow Analysis-Impact of Oxidative Stress on Disease Severity.International journal of molecular sciences · 2024Article
- Bio-inspired microfluidics: A review.Biomicrofluidics · 2023Review
- Biomechanical Investigation of Red Cell Sedimentation Using Blood Shear Stress and Blood Flow Image in a Capillary Chip.Micromachines · 2023Article
- Comparative impact of streptozotocin on altering normal glucose homeostasis in diabetic rats compared to normoglycemic rats.Scientific reports · 2023Article
- Advances in Microfluidics for Single Red Blood Cell Analysis.Biosensors · 2023Review
- Preliminary Study of Genome-Wide Association Identified Novel Susceptibility Genes for Hemorheological Indexes in a Chinese Population.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2022Article
- Neural network ensemble model for prediction of erythrocyte sedimentation rate (ESR) using partial least squares regression.Scientific reports · 2022Article
- Red Blood Cell Sedimentation Index Using Shear Stress of Blood Flow in Microfluidic Channel.Biosensors · 2022Article
- Contributions of Red Blood Cell Sedimentation in a Driving Syringe to Blood Flow in Capillary Channels.Micromachines · 2022Article
- Improved Erythrocyte Deformability Induced by Sodium-Glucose Cotransporter 2 Inhibitors in Type 2 Diabetic Patients.Cardiovascular drugs and therapy · 2022Article
- Imaging Erythrocyte Sedimentation in Whole Blood.Frontiers in physiology · 2021Article
- Visualization and Measurements of Blood Cells Flowing in Microfluidic Systems and Blood Rheology: A Personalized Medicine Perspective.Journal of personalized medicine · 2020Review
- Intraoperative Laser Speckle Contrast Imaging For Real-Time Visualization of Cerebral Blood Flow in Cerebrovascular Surgery: Results From Pre-Clinical Studies.Scientific reports · 2020Article
- Experimental Investigation of Air Compliance Effect on Measurement of Mechanical Properties of Blood Sample Flowing in Microfluidic Channels.Micromachines · 2020Article
- Microfluidic-Based Biosensor for Blood Viscosity and Erythrocyte Sedimentation Rate Using Disposable Fluid Delivery System.Micromachines · 2020Article
- A portable rotating disc as blood rheometer.Biomicrofluidics · 2019Article
- Microfluidic-Based Biosensor for Sequential Measurement of Blood Pressure and RBC Aggregation Over Continuously Varying Blood Flows.Micromachines · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biochemical alterations in the plasma and red blood cell (RBC) membrane of diabetic blood lead to excessive erythrocyte aggregation (EA). EA would significantly impede the blood flow and increase the vascular flow resistance contributing to peripheral vascular diseases. In this study, a simple microfluidic-based method is proposed to achieve sensitive detection of hyperaggregation. When a blood sample is delivered into the device, images of blood flows are obtained with a short exposure time for a relatively long measuring time. A micro-particle image velocimetry technique was employed to monitor variation of the flow rate of blood as a function of time. Given that EA formation in the channel creates clear speckle patterns, the EA extent can be estimated by calculating a speckle area (ASpeckle) through a normalized autocovariance function. The hematocrit effect is assessed by comparing optical images transmitted through blood samples. EA variations caused by dextran treatment are quantitatively evaluated using characteristic time (λSpeckle) obtained by fitting the variations of ASpeckle. Other indices including number of RBCs in an aggregate (NRBC), characteristic time of erythrocyte sedimentation rate (λESR), and aggregation index estimated from ultrasound signals (AIEcho) are determined under different EA conditions using conventional techniques. The four different methods are applied to diabetic blood samples to compare their indices under hyperaggregation conditions. It is found that the proposed method can detect variation of EA reasonably, compared with conventional measurement techniques. These experimental demonstrations support the notion that the proposed method is capable of effectively monitoring the biophysical properties of diabetic blood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.