ArticleBiomicrofluidics2015
Measurement of single leukemia cell's density and mass using optically induced electric field in a microfluidics chip.
Article in Biomicrofluidics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Physical Forces in Glioblastoma Migration: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Single-cell mass-density measurements using microchannel gradient centrifugation.Scientific reports · 2026Article
- Biomechanics of circulating cellular and subcellular bioparticles: beyond separation.Cell communication and signaling : CCS · 2024Review
- A computational model for the transit of a cancer cell through a constricted microchannel.Biomechanics and modeling in mechanobiology · 2023Article
- Measurement of Charge and Refractive Indices in Optically Trapped and Ionized Living Cells.Tomography (Ann Arbor, Mich.) · 2022Article
- Deformation of an Encapsulated Leukemia HL60 Cell through Sudden Contractions of a Microfluidic Channel.Micromachines · 2021Article
- Improving viability of leukemia cells by tailoring shell fluid rheology in constricted microcapillary.Scientific reports · 2020Article
- Determination of Dielectric Properties of Cells using AC Electrokinetic-based Microfluidic Platform: A Review of Recent Advances.Micromachines · 2020Review
- A Review on Optoelectrokinetics-Based Manipulation and Fabrication of Micro/Nanomaterials.Micromachines · 2020Review
- Chemo-treated 4T1 breast cancer cells radiation response measured by single and multiple cell ionization using infrared laser trap.Scientific reports · 2019Article
- Optoelectrokinetics-based microfluidic platform for bioapplications: A review of recent advances.Biomicrofluidics · 2019Review
- A microfluidic chip-based co-culture of fibroblast-like synoviocytes with osteoblasts and osteoclasts to test bone erosion and drug evaluation.Royal Society open science · 2018Article
- Analysis of the dielectrophoretic properties of cells using the isomotive AC electric field.Biomicrofluidics · 2018Article
- Determination of Cell Membrane Capacitance and Conductance via Optically Induced Electrokinetics.Biophysical journal · 2017Article
- Preface to Special Topic: Select Papers from the 8th IEEE International Conference on Nano/Molecular Medicine and Engineering Held in Kaohsiung, Taiwan.Biomicrofluidics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a method capable of rapidly (∼20 s) determining the density and mass of a single leukemic cell using an optically induced electrokinetics (OEK) platform. Our team had reported recently on a technique that combines sedimentation theory, computer vision, and micro particle manipulation techniques on an OEK microfluidic platform to determine the mass and density of micron-scale entities in a fluidic medium; the mass and density of yeast cells were accurately determined in that prior work. In the work reported in this paper, we further refined the technique by performing significantly more experiments to determine a universal correction factor to Stokes' equation in expressing the drag force on a microparticle as it falls towards an infinite plane. Specifically, a theoretical model for micron-sized spheres settling towards an infinite plane in a microfluidic environment is presented, and which was validated experimentally using five different sizes of micro polystyrene beads. The same sedimentation process was applied to two kinds of leukemic cancer cells with similar sizes in an OEK platform, and their density and mass were determined accordingly. Our tests on mouse lymphocytic leukemia cells (L1210) and human leukemic cells (HL-60) have verified the practical viability of this method. Potentially, this new method provides a new way of measuring the volume, density, and mass of a single cell in an accurate, selective, and repeatable manner.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.