Evidence map›Paper›PMID 25945121›Full record

ReviewComputational and mathematical methods in medicine2015

MRI segmentation of the human brain: challenges, methods, and applications.

Ivana Despotović, Bart Goossens, Wilfried Philips

Abstract readReview
In one paragraph

Review in Computational and mathematical methods in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 180 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
180citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

180 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  6. Brain atrophy in cerebral small vessel diseases: Extent, consequences, technical limitations and perspectives: The HARNESS initiative.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Pooled it
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  8. Article
  9. Advances in Wearable Bioimaging.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
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  15. A review of 3D printed medical implant design.3D printing in medicine · 2026
    Article
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  17. Neuroimaging and consciousness: applications of PET, SPECT, and advanced MRI modalities.American journal of nuclear medicine and molecular imaging · 2026
    Review
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120 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ivana DespotovićDepartment of Telecommunications and Information Processing TELIN-IPI-iMinds, Ghent University, St-Pietersnieuwstraat 41, 9000 Ghent, Belgium.
Bart GoossensDepartment of Telecommunications and Information Processing TELIN-IPI-iMinds, Ghent University, St-Pietersnieuwstraat 41, 9000 Ghent, Belgium.ORCID 0000-0002-4942-132X
Wilfried PhilipsDepartment of Telecommunications and Information Processing TELIN-IPI-iMinds, Ghent University, St-Pietersnieuwstraat 41, 9000 Ghent, Belgium.ORCID 0000-0003-4456-4353

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Image segmentation is one of the most important tasks in medical image analysis and is often the first and the most critical step in many clinical applications. In brain MRI analysis, image segmentation is commonly used for measuring and visualizing the brain's anatomical structures, for analyzing brain changes, for delineating pathological regions, and for surgical planning and image-guided interventions. In the last few decades, various segmentation techniques of different accuracy and degree of complexity have been developed and reported in the literature. In this paper we review the most popular methods commonly used for brain MRI segmentation. We highlight differences between them and discuss their capabilities, advantages, and limitations. To address the complexity and challenges of the brain MRI segmentation problem, we first introduce the basic concepts of image segmentation. Then, we explain different MRI preprocessing steps including image registration, bias field correction, and removal of nonbrain tissue. Finally, after reviewing different brain MRI segmentation methods, we discuss the validation problem in brain MRI segmentation.

Indexed as

AlgorithmsBrainBrain MappingCluster AnalysisHumansImage Processing, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingNormal DistributionReproducibility of ResultsSoftware

Identifiers

PMID25945121
PMCPMC4402572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.