ReviewClinical epidemiology2015
Cushing's syndrome: epidemiology and developments in disease management.
Review in Clinical epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
122 citing papers in PubMed, 5 syntheses or guidelines pooled it, 204 citations in OpenAlex.
- Ectopic ACTH Syndrome Caused by Pheochromocytoma: A Case Report and Systematic Review.Endocrine, metabolic & immune disorders drug targets · 2026Pooled it
- Plasma Cortisol and Risk of Atrial Fibrillation: A Mendelian Randomization Study.The Journal of clinical endocrinology and metabolism · 2021Pooled it
- Two types of ectopic Cushing syndrome or a continuum? Review.Pituitary · 2018Pooled it
- Pooled it
- Updates on the role of adrenal steroidogenesis inhibitors in Cushing's syndrome: a focus on novel therapies.Pituitary · 2016Pooled it
- An observational study of menstrual function and related hormones before and after treatment of Cushing syndrome.Journal of the Endocrine Society · 2026Article
- Cushing disease and unilateral primary aldosteronism confounded by a nonfunctioning contralateral adrenal incidentaloma.JCEM case reports · 2026Article
- Severe Ectopic ACTH-Dependent Cushing Syndrome Due to a Neuroendocrine Tumor of Occult Primary Origin Presenting with Widespread Metastases and Early Vertebral Fractures: A Rare Case Report.International medical case reports journal · 2026Article
- Clinical characteristics, diagnosis, and treatment of Cushing's syndrome: analysis of a multicenter registry in Antioquia, Colombia.Therapeutic advances in endocrinology and metabolism · 2026Article
- cAMP/PKA signaling in endocrine hypertension: genetic mechanisms and pathophysiological insights.Frontiers in endocrinology · 2026Review
- Ectopic Adrenocorticotropic Hormone (ACTH) Syndrome Caused by Mediastinal Carcinoma: A Report of a Rare Case.Cureus · 2026Article
- Clinical features, comorbidities, and therapeutic outcomes of Cushing syndrome: a retrospective multicenter study from Saudi Arabia.Frontiers in endocrinology · 2026Article
- Update in the Management of ACTH-Secreting Gastroenteropancreatic and Thoracic Neuroendocrine Neoplasms.Current treatment options in oncology · 2025Review
- Co-Occurrence of Endogenous and Exogenous Cushing's Syndromes: Does "Double Cushing Syndrome" Really Exist? A Case Report.Clinical case reports · 2025Article
- Delirium Induced by Rapid Titration of Osilodrostat in a Patient With Cushing's Disease: A Case Report.Cureus · 2025Article
- Adrenal hemorrhage: diagnostics, management, and treatment. Review and clinical update.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2025Review
- Article
- Long-term outcomes and survival predictors in patients with ectopic ACTH syndrome: data from a retrospective cohort study.Endocrine connections · 2025Article
- Radiofrequency Ablation: Alternative Treatment of Ectopic Adrenocorticotropic Syndrome Secondary to Lung Carcinoid Tumor.JCEM case reports · 2025Article
- Matching-Adjusted Indirect Comparison of Osilodrostat Versus Metyrapone for the Treatment of Cushing's Syndrome.Advances in therapy · 2025Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Cushing's syndrome is a rare disorder resulting from prolonged exposure to excess glucocorticoids. Early diagnosis and treatment of Cushing's syndrome is associated with a decrease in morbidity and mortality. Clinical presentation can be highly variable, and establishing the diagnosis can often be difficult. Surgery (resection of the pituitary or ectopic source of adrenocorticotropic hormone, or unilateral or bilateral adrenalectomy) remains the optimal treatment in all forms of Cushing's syndrome, but may not always lead to remission. Medical therapy (steroidogenesis inhibitors, agents that decrease adrenocorticotropic hormone levels or glucocorticoid receptor antagonists) and pituitary radiotherapy may be needed as an adjunct. A multidisciplinary approach, long-term follow-up, and treatment modalities customized to each individual are essential for optimal control of hypercortisolemia and management of comorbidities.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.