SynthesisInternational journal of chronic obstructive pulmonary disease2015
Effectiveness of pulmonary rehabilitation in COPD with mild symptoms: a systematic review with meta-analyses.
Synthesis in International journal of chronic obstructive pulmonary disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Pulmonary Rehabilitation for Adults with Chronic Respiratory Disease: An Official American Thoracic Society Clinical Practice Guideline.American journal of respiratory and critical care medicine · 2023Guideline
- Low-intensity educational interventions supporting self-management to improve outcomes related to chronic breathlessness: a systematic review.NPJ primary care respiratory medicine · 2019Pooled it
- Effects of pulmonary rehabilitation in lung transplant candidates: a systematic review.BMJ open · 2017Pooled it
- Coherence between self-reported and objectively measured physical activity in patients with chronic obstructive lung disease: a systematic review.International journal of chronic obstructive pulmonary disease · 2016Pooled it
- Using step counters to promote physical activity and exercise capacity in patients with chronic obstructive pulmonary disease: a meta-analysis.Therapeutic advances in respiratory diseasePooled it
- Trial
- Benefits of different intensities of pulmonary rehabilitation for patients with moderate-to-severe COPD according to the GOLD stage: a prospective, multicenter, single-blinded, randomized, controlled trial.International journal of chronic obstructive pulmonary disease · 2019Trial
- Current practices, perceptions and future challenges in the management of moderate to severe COPD: a cross-sectional survey of respiratory consultants in the Republic of Ireland.BMJ open respiratory research · 2025Article
- Effects of pulmonary rehabilitation on systemic inflammation in chronic obstructive pulmonary disease: a meta-analysis.American journal of clinical and experimental immunology · 2024Review
- Effects of continuous aerobic training associated with resistance training on maximal and submaximal exercise tolerance, fatigue, and quality of life of patients post-COVID-19.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2023Article
- Current Progress of COPD Early Detection: Key Points and Novel Strategies.International journal of chronic obstructive pulmonary disease · 2023Review
- Effectiveness of Pulmonary Rehabilitation Performed Through Exercise Training for Patients with Stable COPD: A Meta-analysis of Randomized Controlled Trials.Zdravstveno varstvo · 2022Article
- Relationships of Walking and non-Walking Physical Activities in Daily Life with Cognitive Function and Physical Characteristics in Male Patients with Mild Chronic Obstructive Pulmonary Disease.Clinical medicine insights. Circulatory, respiratory and pulmonary medicine · 2022Article
- Chronic Obstructive Pulmonary Disease: Proprioception Exercises as an Addition to the Rehabilitation Process.Cureus · 2020Review
- What still prevents to acknowledge a major role for pulmonary rehabilitation in COPD treatment?Acta bio-medica : Atenei Parmensis · 2019Article
- Baseline Exercise Tolerance and Perceived Dyspnea to Identify the Ideal Candidate to Pulmonary Rehabilitation: A Risk Chart in COPD Patients.International journal of chronic obstructive pulmonary disease · 2019Article
- Long-term endurance running activity causes pulmonary changes depending on the receptor for advanced glycation end-products.Pflugers Archiv : European journal of physiology · 2018Article
- Outcomes of community-based and home-based pulmonary rehabilitation for pneumoconiosis patients: a retrospective study.BMC pulmonary medicine · 2018Article
- Barriers and enablers of COPD telerehabilitation - a frontline staff perspective.International journal of chronic obstructive pulmonary disease · 2018Article
- Can CAPTURE be used to identify undiagnosed patients with mild-to-moderate COPD likely to benefit from treatment?International journal of chronic obstructive pulmonary disease · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMost guidelines recommend pulmonary rehabilitation (PR) for patients with chronic obstructive pulmonary disease (COPD) and modified Medical Research Council dyspnea scale (mMRC) levels ≥2, but the effectiveness of PR in patients with less advanced disease is not well established. Our aim was to investigate the effects of PR in patients with COPD and mMRC ≤1.
methodsThe methodology was developed as a part of evidence-based guideline development and is in accordance with the principles of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group. We identified randomized controlled trials (RCTs) through a systematic, multidatabase literature search and selected RCTs comparing the effects of PR with usual care in patients with COPD and mMRC ≤1. Predefined critical outcomes were health-related quality of life (HRQoL), adverse effects and mortality, while walking distance, maximal exercise capacity, muscle strength, and dropouts were important outcomes. Two authors independently extracted data, assessed trial eligibility and risk of bias, and graded the evidence. Meta-analyses were performed when deemed feasible.
resultsFour RCTs (489 participants) were included. On the basis of moderate-quality evidence, we found a clinically and statistically significant improvement in short-term HRQoL of 4.2 units (95% confidence interval [CI]: [-4.51 to -3.89]) on St George's Respiratory Questionnaire, but not at the longest follow-up. We also found a statistically significant improvement of 25.71 m (95% CI: [15.76-35.65]) in the 6-minute walk test with PR; however, this improvement was not considered clinically relevant. No difference was found for mortality, and insufficient data prohibited meta-analysis for muscle strength and maximal exercise capacity. No adverse effects were reported.
conclusionWe found a moderate quality of evidence suggesting a small, significant improvement in short-term HRQoL and a clinically nonsignificant improvement in walking distance following PR in patients with COPD and mild symptoms. This resulted in a weak recommendation of routine PR in these patients using the GRADE approach.
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Registered trials
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