ArticleRegulatory toxicology and pharmacology : RTP2015
Technical guide for applications of gene expression profiling in human health risk assessment of environmental chemicals.
Article in Regulatory toxicology and pharmacology : RTP, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Integrative methylome and transcriptome analysis reveals genotype and sequence context-specific responses to aluminum stress in rice.Frontiers in plant science · 2026Article
- Utilizing rat kidney gene co-expression networks to enhance safety assessment biomarker identification and human translation.iScience · 2025Article
- Extracellular Vesicle (EV) Mechanisms of Toxicity for Per and Polyfluoroalkyl Substances: Comparing Transcriptomic Points of Departure Across Global Versus EV Regulatory Gene Sets.Environmental and molecular mutagenesis · 2025Article
- Computational Strategies for Assessing Adverse Outcome Pathways: Hepatic Steatosis as a Case Study.International journal of molecular sciences · 2024Review
- Investigating the dependency of in vitro benchmark concentrations on exposure time in transcriptomics experiments.Toxicology in vitro : an international journal published in association with BIBRA · 2024Article
- A Multiplex Gene Expression Assay for Direct Measurement of RNA Transcripts in Crude Lysates of the Nematode Caenorhabditis elegans Used as a Bioanalytical Tool.Environmental toxicology and chemistry · 2023Article
- 3' RNA-seq is superior to standard RNA-seq in cases of sparse data but inferior at identifying toxicity pathways in a model organism.Frontiers in bioinformatics · 2023Article
- From vision toward best practices: EvaluatingFrontiers in toxicology · 2023Article
- Wildfire Variable Toxicity: Identifying Biomass Smoke Exposure Groupings through Transcriptomic Similarity Scoring.Environmental science & technology · 2022Article
- Integrative exposomic, transcriptomic, epigenomic analyses of human placental samples links understudied chemicals to preeclampsia.Environment international · 2022Article
- Repeat-dose toxicity prediction with Generalized Read-Across (GenRA) using targeted transcriptomic data: A proof-of-concept case study.Computational toxicology (Amsterdam, Netherlands) · 2021Article
- A cross-sector call to improve carcinogenicity risk assessment through use of genomic methodologies.Regulatory toxicology and pharmacology : RTP · 2020Article
- Next generation sequencing data for use in risk assessment.Current opinion in toxicology · 2019Article
- The use of evidence from high-throughput screening and transcriptomic data in human health risk assessments.Toxicology and applied pharmacology · 2019Article
- Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with in Vitro Testing and Adverse Outcome Pathway Approaches.Environmental health perspectives · 2019Article
- Methods for the analysis of transcriptome dynamics.Toxicology research · 2019Review
- Gene networking in colistin-induced nephrotoxicity reveals an adverse outcome pathway triggered by proteotoxic stress.International journal of molecular medicine · 2019Article
- Developments in toxicogenomics: understanding and predicting compound-induced toxicity from gene expression data.Molecular omics · 2018Review
- Benchmark Dose Modeling Estimates of the Concentrations of Inorganic Arsenic That Induce Changes to the Neonatal Transcriptome, Proteome, and Epigenome in a Pregnancy Cohort.Chemical research in toxicology · 2017Article
- The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment.Toxicological sciences : an official journal of the Society of Toxicology · 2017Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Toxicogenomics promises to be an important part of future human health risk assessment of environmental chemicals. The application of gene expression profiles (e.g., for hazard identification, chemical prioritization, chemical grouping, mode of action discovery, and quantitative analysis of response) is growing in the literature, but their use in formal risk assessment by regulatory agencies is relatively infrequent. Although additional validations for specific applications are required, gene expression data can be of immediate use for increasing confidence in chemical evaluations. We believe that a primary reason for the current lack of integration is the limited practical guidance available for risk assessment specialists with limited experience in genomics. The present manuscript provides basic information on gene expression profiling, along with guidance on evaluating the quality of genomic experiments and data, and interpretation of results presented in the form of heat maps, pathway analyses and other common approaches. Moreover, potential ways to integrate information from gene expression experiments into current risk assessment are presented using published studies as examples. The primary objective of this work is to facilitate integration of gene expression data into human health risk assessments of environmental chemicals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.