ArticleParasitology research2015
Interaction of carvacrol with the Ascaris suum nicotinic acetylcholine receptors and gamma-aminobutyric acid receptors, potential mechanism of antinematodal action.
Article in Parasitology research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Neuromuscular System of Nematodes Is a Target of Synergistic Pharmacological Effects of Carvacrol and Geraniol.Pharmaceuticals (Basel, Switzerland) · 2025Article
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- Anthelmintic activity of winter savory (Satureja montana L.) essential oil against gastrointestinal nematodes of sheep.BMC veterinary research · 2025Article
- Unraveling anthelmintic targets and mechanisms of action of trans-cinnamaldehyde from cinnamon essential oil.Scientific reports · 2025Article
- Pharmacological effects of monoterpene carveol on the neuromuscular system of nematodes and mammals.Frontiers in pharmacology · 2024Article
- Do combinations of fipronil, eugenol and carvacrol have synergistic effects against Rhipicephalus sanguineus?Parasitology research · 2023Article
- Article
- A Potential Anthelmintic Phytopharmacological Source ofAnimals : an open access journal from MDPI · 2022Article
- Action of Carvacrol onPharmaceuticals (Basel, Switzerland) · 2021Article
- Interaction of agonists of a different subtype of the nAChR and carvacrol with GABA inJournal of nematology · 2021Article
- Evaluation ofFrontiers in cellular and infection microbiology · 2021Article
- Caenorhabditis elegans muscle Cys-loop receptors as novel targets of terpenoids with potential anthelmintic activity.PLoS neglected tropical diseases · 2019Article
- Menthol acts as a positive allosteric modulator on nematode levamisole sensitive nicotinic acetylcholine receptors.International journal for parasitology. Drugs and drug resistance · 2019Article
- Essential Oils and Their Constituents Targeting the GABAergic System and Sodium Channels as Treatment of Neurological Diseases.Molecules (Basel, Switzerland) · 2018Review
- Monepantel is a non-competitive antagonist of nicotinic acetylcholine receptors from Ascaris suum and Oesophagostomum dentatum.International journal for parasitology. Drugs and drug resistance · 2018Article
- Green drugs in the fight against Anisakis simplex-larvicidal activity and acetylcholinesterase inhibition of Origanum compactum essential oil.Parasitology research · 2018Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Essential plant oils (or their active principles) are safe to use and a potentially attractive alternative to current antiparasitic drugs. In the present study, we tested the effects of carvacrol on the isolated tissues of Ascaris suum and investigated potential interactions with other antiparasitic drugs. We used somatic muscle flaps for contraction assays, as well as for electrophysiological investigations. Carvacrol 300 μM highly significantly inhibited contractions caused by 1, 3, 10, 30, and 100 μM of ACh (p = 0.0023, p = 0.0002, p = 0.0002, p < 0.0001, and p < 0.0001). The control EC50 for acetylcholine was 8.87 μM (log EC50 = 0.95 ± 0.26), while R max was 2.53 ± 0.24 g. The EC50 of acetylcholine in the presence of 300 μM of carvacrol was 27.71 μM (log EC50 = 1.44 ± 0.28) and the R max decreased to 1.63 ± 0.32 g. Furthermore, carvacrol highly significant potentiates inhibitory effect of GABA and piperazine on the contractions induced by ACh. However, carvacrol (100 and 300 μM), did not produce any changes in the membrane potential or conductance of the A. suum muscle cell. While, 300 μM of carvacrol showed a significant inhibitory effect on ACh-induced depolarization response. The mean control depolarization was 13.58 ± 0.66 mV and decreased in presence of carvacrol to 4.50 ± 1.02 mV (p < 0.0001). Mean control Δg was 0.168 ± 0.017 μS, while in the presence of 300 μM of carvacrol, Δg significantly decreased to 0.060 ± 0.018 ΔS (p = 0.0017). The inhibitory effect on contractions may be the explanation of the antinematodal potential of carvacrol. Moreover, inhibition of depolarizations caused by ACh and reduction of conductance changes directly points to an interaction with the nAChR in A. suum.
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