Evidence map›Paper›PMID 25944697›Full record

ArticleOncotarget2015

Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population.

Chao Yang, Ran Tang, Xiang Ma, Younan Wang, Dakui Luo, Zekuan Xu, Yi Zhu, Li Yang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 12 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 12 syntheses or guidelines pooled it, 137 citations in OpenAlex.

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  10. Perspectives of long non-coding RNAs in cancer.Molecular biology reports · 2017
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chao YangDepartment of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Ran TangDepartment of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Xiang MaDepartment of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Younan WangDepartment of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Dakui LuoDepartment of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zekuan XuDepartment of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yi ZhuDepartment of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Li YangDepartment of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Nanjing Medical University · CNJiangsu Province Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNA (lncRNA) H19 is involved in tumor development, progression, and metastasis. This case-control study assessed the association between H19 genetic variants and susceptibility to gastric cancer (GC) in a Chinese Han population. We genotyped four lncRNA H19 single nucleotide polymorphisms (SNPs) (rs217727 C > T, rs2839698 C > T, rs3741216 A > T, rs3741219 T > C) in 500 GC patients and 500 healthy controls. Carriers of variant rs217727T and rs2839698T alleles showed increased GC risk (P = 0.008 and 0.011, respectively). Compared with the common genotype, CT + TT rs217727 and CT + TT rs2839698 genotypes were associated with significantly increased GC risk (P = 0.040, adjusted odds ratio [OR] = 1.32, 95% confidence interval [CI] = 1.01-1.71; P = 0.033, adjusted OR = 1.31, 95% CI = 1.02-1.69, respectively). Further stratified analyses revealed that the association between GC risk and variant genotypes of rs217727 was more profound in younger individuals (≤59 years) and non-smokers, while the association between risk and the rare rs2839698 genotype persisted in men and rural subjects. rs2839698 CT and TT genotypes were also associated with higher serum H19 mRNA levels compared with the CC genotype. These findings suggest that lncRNA H19 SNPs may contribute to susceptibility to GC.

Indexed as

Genetic Predisposition to DiseaseAgingCase-Control StudiesChinaFemaleGenetic Association StudiesGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotideRNA, Long NoncodingRNA, MessengerStomach NeoplasmsSurveys and QuestionnairesH19 long non-coding RNARNA, Long NoncodingRNA, Messengergastric cancergenotypeH19polymorphism

Identifiers

PMID25944697
PMCPMC4558153
OpenAlexW1769313417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.