ReviewWorld journal of urology2015
Histological outcomes after focal high-intensity focused ultrasound and cryotherapy.
Review in World journal of urology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Complications, oncological and functional outcomes of salvage treatment options following focal therapy for localized prostate cancer: a systematic review and a comprehensive narrative review.World journal of urology · 2019Pooled it
- Trial
- Post-radiation simple cystectomy for end-stage bladder in cancer survivors is not associated with occult malignancy.World journal of urology · 2025Article
- Surveillance one year post focal cryotherapy for clinically significant prostate cancer using mpMRI and PIRADS v2.1: An initial experience from a prospective phase II mandatory biopsy study.European journal of radiology open · 2023Article
- Focal therapy for localized prostate cancer in the era of routine multi-parametric MRI.Prostate cancer and prostatic diseases · 2020Review
- T cells CD4+/CD8+ local immune modulation by prostate cancer hemi-cryoablation.World journal of urology · 2020Observational
- Cytoreductive treatment strategies for de novo metastatic prostate cancer.Nature reviews. Clinical oncology · 2020Review
- HIFU, a noninvasive and effective treatment for chyluria: 15 years of experience.Surgical endoscopy · 2018Article
- Which technology to select for primary focal treatment of prostate cancer?-European Section of Urotechnology (ESUT) position statement.Prostate cancer and prostatic diseases · 2018Review
- 3D Registration of mpMRI for Assessment of Prostate Cancer Focal Therapy.Academic radiology · 2017Article
- Utilization of multiparametric prostate magnetic resonance imaging in clinical practice and focal therapy: report from a Delphi consensus project.World journal of urology · 2017Article
- Robotic Assisted Laparoscopic Prostatectomy after High Intensity Focused Ultrasound Failure.Case reports in urology · 2017Article
- Management of low- and intermediate-risk prostate cancer.World journal of urology · 2015Article
- Initial single-centre Canadian experience with 18F-fluoromethylcholine positron emission tomography-computed tomography (18F-FCH PET/CT) for biochemical recurrence in prostate cancer patients initially treated with curative intent.Canadian Urological Association journal = Journal de l'Association des urologues du CanadaArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionFocal therapy has increasingly become an accepted treatment option for patients with localised prostate cancer. Most follow-up protocols use a mixture of protocol biopsies or "for cause" biopsies triggered by a rising PSA. In this paper, we discuss the histological outcomes from these biopsies and their use in guiding subsequent management and trial development.
methodsWe conducted a literature search and reviewed the post-treatment biopsy results from studies on focal HIFU and focal cryotherapy. We subsequently reviewed the results of three recently published consensus statements released discussing many of the issues concerning focal therapy.
resultsResearch suggests that 1 in 5 of all post-treatment biopsies after focal therapy are positive. However, the majority of these seemed to be from the untreated portion of the gland or met criteria for clinically insignificant disease. The histological outcomes from focal therapy are promising and confirm its effectiveness in the short to medium term. Furthermore re-treatment is possible whilst maintaining a low-side-effect profile.
conclusionDebate is ongoing about the clinical significance of various levels of residual disease after focal therapy and the exact threshold at which to call failure within a patient who has had focal therapy.
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