Evidence map›Paper›PMID 25944593›Full record

ReviewJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2015

Expanding applications, accuracy, and interpretation of laser speckle contrast imaging of cerebral blood flow.

S M Shams Kazmi, Lisa M Richards, Christian J Schrandt, Mitchell A Davis, Andrew K Dunn

Abstract readReview
In one paragraph

Review in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Preclinical in-vivo cerebrovascular imaging in rodent models: Methods and applications in Alzheimer's disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  2. Article
  3. NFAT1Cellular & molecular biology letters · 2026
    Article
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  6. Article
  7. Article
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  12. Article
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  14. Review
  15. A brief overview of a mouse model of cerebral hypoperfusion by bilateral carotid artery stenosis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

S M Shams KazmiDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, USA.
Lisa M RichardsDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, USA.
Christian J SchrandtDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, USA.
Mitchell A DavisDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, USA.
Andrew K DunnDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, USA.

Funding

Optical Imaging of Baseline Blood Flow and Oxygenation During StrokeR01EB011556 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI DUNN, ANDREW K · 2010 to 2018
$3.1M
Comprehensive Training Program in Imaging Science and InformaticsT32EB007507 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI MARKEY, MIA K, RYLANDER, HENRY GRADY · 2009 to 2024
$2.7M
Microscale Oxygenation Mapping During StrokeR01NS082518 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI DUNN, ANDREW K · 2013 to 2017
$1.7M
Neurovascular Mechanisms of Time-Dependencies in Stroke RehabilitationR01NS078791 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI DUNN, ANDREW K, JONES, THERESA A · 2012 to 2016
$1.7M
NIBIB NIH HHS R01 EB011556NIBIB NIH HHS T32 EB007507NINDS NIH HHS R01 NS078791NINDS NIH HHS R01 NS082518
6 · The paper itself

Abstract

Laser speckle contrast imaging (LSCI) provides a rapid characterization of cortical flow dynamics for functional monitoring of the microcirculation. The technique stems from interactions of laser light with moving particles. These interactions encode the encountered Doppler phenomena within a random interference pattern imaged in widefield, known as laser speckle. Studies of neurovascular function and coupling with LSCI have benefited from the real-time characterization of functional dynamics in the laboratory setting through quantification of perfusion dynamics. While the technique has largely been relegated to acute small animal imaging, its scalability is being assessed and characterized for both chronic and clinical neurovascular imaging.

Indexed as

Cerebrovascular CirculationContrast MediaAnimalsBrainHumansLaser-Doppler FlowmetryContrast Media

Identifiers

PMID25944593
PMCPMC4640282

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.