ArticleScientific reports2015
Developmentally dynamic genome: Evidence of genetic influences on increases and decreases in conduct problems from early childhood to adolescence.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Parenting Characteristics and Callous-Unemotional Traits in Children Aged 0-6 Years: A Systematic Narrative Review.Child psychiatry and human development · 2025Pooled it
- Long-term follow-up of a randomised controlled trial of a brief home-based parenting intervention to reduce behavioural problems in young children.Journal of child psychology and psychiatry, and allied disciplines · 2026Trial
- A video-feedback parenting intervention to prevent enduring behaviour problems in at-risk children aged 12-36 months: the Healthy Start, Happy Start RCT.Health technology assessment (Winchester, England) · 2021Trial
- Psychiatric and substance use disorder polygenic scores are associated with the exposome in youth.European child & adolescent psychiatry · 2026Article
- Built Environment-Modulated Epigenetics: The Epigenetic Consequences of Architecturally Mediated Allostatic Overload in the Built Environment.International journal of environmental research and public health · 2026Review
- Annual Research Review: Early conduct problems - precursors, outcomes, and etiology.Journal of child psychology and psychiatry, and allied disciplines · 2026Review
- Using twin-pairs to assess potential bias in polygenic prediction of externalising behaviours across development.Molecular psychiatry · 2025Article
- Research Review: A review of the past decade of family and genomic studies on adolescent mental health.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- Examining intergenerational risk factors for conduct problems using polygenic scores in the Norwegian Mother, Father and Child Cohort Study.Molecular psychiatry · 2024Article
- Using twin-pairs to assess potential bias in polygenic prediction of externalising behaviours across development.medRxiv : the preprint server for health sciences · 2023Article
- The general psychopathology factor (Development and psychopathology · 2023Article
- Research Review: A guide to computing and implementing polygenic scores in developmental research.Journal of child psychology and psychiatry, and allied disciplines · 2022Review
- Developmental co-occurrence of psychopathology dimensions in childhood.JCPP advances · 2022Article
- Why do depression, conduct, and hyperactivity symptoms co-occur across adolescence? The role of stable and dynamic genetic and environmental influences.European child & adolescent psychiatry · 2021Article
- Genetic and environmental influences on the developmental trajectory of callous-unemotional traits from childhood to adolescence.Journal of child psychology and psychiatry, and allied disciplines · 2021Article
- The developmental course of inattention symptoms predicts academic achievement due to shared genetic aetiology: a longitudinal twin study.European child & adolescent psychiatry · 2019Article
- The Associations between Callous-unemotional Traits and Symptoms of Conduct Problems, Hyperactivity and Emotional Problems: A Study of Adolescent Twins Screened for Neurodevelopmental Problems.Journal of abnormal child psychology · 2019Article
- Neonatal DNA methylation and early-onset conduct problems: A genome-wide, prospective study.Development and psychopathology · 2018Article
- Behavioral Variability and Somatic Mosaicism: A Cytogenomic Hypothesis.Current genomics · 2018Review
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The development of conduct problems in childhood and adolescence is associated with adverse long-term outcomes, including psychiatric morbidity. Although genes constitute a proven factor of stability in conduct problems, less is known regarding their role in conduct problems' developmental course (i.e. systematic age changes, for instance linear increases or decreases).Mothers rated conduct problems from age 4 to 16 years in 10,038 twin pairs from the Twins Early Development Study. Individual differences in the baseline level (.78; 95% CI: .68-.88) and the developmental course of conduct problems (.73; 95% CI: .60-.86) were under high and largely independent additive genetic influences. Shared environment made a small contribution to the baseline level but not to the developmental course of conduct problems. These results show that genetic influences not only contribute to behavioural stability but also explain systematic change in conduct problems. Different sets of genes may be associated with the developmental course versus the baseline level of conduct problems. The structure of genetic and environmental influences on the development of conduct problems suggests that repeated preventive interventions at different developmental stages might be necessary to achieve a long-term impact.
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Registered trials
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