ReviewChromosoma2015
Nuclear roles for actin.
Review in Chromosoma, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Role of WAVE3 as an actin binding protein in the pathology of triple negative breast cancer.Cytoskeleton (Hoboken, N.J.) · 2025Review
- Normalization strategy for selection of reference genes for RT-qPCR analysis in left ventricles of failing human hearts.BMC cardiovascular disorders · 2022Article
- The prophase oocyte nucleus is a homeostatic G-actin buffer.Journal of cell science · 2022Article
- Ezh2 harnesses the intranuclear actin cytoskeleton to remodel chromatin in differentiating Th cells.iScience · 2021Article
- The Significant Role of the Microfilament System in Tumors.Frontiers in oncology · 2021Review
- Regulation of actin isoforms in cellular and developmental processes.Seminars in cell & developmental biology · 2020Review
- Posttranscriptional and Posttranslational Regulation of Actin.Anatomical record (Hoboken, N.J. : 2007) · 2018Review
- ACTB Loss-of-Function Mutations Result in a Pleiotropic Developmental Disorder.American journal of human genetics · 2017Article
- Actin, actin-binding proteins, and actin-related proteins in the nucleus.Histochemistry and cell biology · 2016Review
- Top Down Proteomics Reveals Mature Proteoforms Expressed in Subcellular Fractions of the Echinococcus granulosus Preadult Stage.Journal of proteome research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Actin's presence in the nucleus is a subject that has ignited a lot of controversy in the past. With our review, we attempt to reach out not only to the specialists but also to a broader audience that might be skeptical in light of the controversies. We take a rather conservative approach to build an argument that recent studies provide multiple independent lines of evidence substantiating actin's diverse nuclear functions, especially in its monomeric state. We then particularly focus on how the concentration of monomeric actin, and potentially of specific polymerized forms of actin, can be used by the cell as indicators of cellular state and how this information can be transduced into the nucleus by transcriptional regulators, eliciting a response. We also provide examples that in specific cell types and specific physiological conditions, actin is functional in the nucleus in its polymeric form. However, we also discuss that in many instances, the presence of actin regulators in the nucleus, which is often seen as proof of their function within this compartment, may simply reflect an additional means of their regulation by compartmentalization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.