Evidence map›Paper›PMID 25943942›Full record

ReviewLancet (London, England)2015

Early chronic obstructive pulmonary disease: definition, assessment, and prevention.

Stephen I Rennard, M Bradley Drummond

Registry-linked trialAbstract readReview
In one paragraph

Review in Lancet (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03263130 (Site and Mechanism), which is not on this map. Cited by 114 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03263130 recruitingnot on this mapstarted 2017, after this paper: background citation

Site and Mechanism(s) of Expiratory Airflow Limitation in COPD, Emphysema and Asthma-COPD Overlap

Typeobservational_patient_registrySponsorGelb, Arthur F., M.D.Ran2017 to 2027Enrolled60ConditionsCOPD, Emphysema, Asthma COPD Overlap, EmphysemaArmsAs above: diagnosis: COPD, Emphysema, Asthma-COPD Overlap
3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  18. Risk and Protective Factors of COPD Among Smokers: A Cross-Sectional Study Using NHANES Database.International journal of chronic obstructive pulmonary disease · 2025
    Article
  19. Article
  20. Lung Health of Early COPD (LHEC): A Multi-Center Cohort Study-Rational and Design.International journal of chronic obstructive pulmonary disease · 2025
    Article

54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Stephen I RennardDepartment of Internal Medicine, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE, USA. Electronic address: srennard@unmc.edu.
M Bradley DrummondJohns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

Mechanisms of COPD Subphenotype DevelopmentK23HL103192 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI DRUMMOND, MICHAEL BRADLEY · 2010 to 2013
$650k
NHLBI NIH HHS K23 HL103192
6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. COPD, however, is a heterogeneous collection of diseases with differing causes, pathogenic mechanisms, and physiological effects. Therefore a comprehensive approach to COPD prevention will need to address the complexity of COPD. Advances in the understanding of the natural history of COPD and the development of strategies to assess COPD in its early stages make prevention a reasonable, if ambitious, goal.

Indexed as

Early Medical InterventionSmoking CessationAlbuterolAndrostadienesAnti-Inflammatory AgentsBronchodilator AgentsDisease ProgressionDrug CombinationsEarly DiagnosisExercise TestFluticasone-Salmeterol Drug CombinationForced Expiratory VolumeHumansPulmonary Disease, Chronic ObstructiveRespiratory Function TestsSeverity of Illness IndexAlbuterolAndrostadienesAnti-Inflammatory AgentsBronchodilator AgentsDrug CombinationsFluticasone-Salmeterol Drug Combination

Identifiers

PMID25943942
PMCPMC4819246

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.