ArticleAge (Dordrecht, Netherlands)2015
Age-related variations of protein carbonyls in human saliva and plasma: is saliva protein carbonyls an alternative biomarker of aging?
Article in Age (Dordrecht, Netherlands), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Effects of stannous fluoride dentifrice on gingival health and oxidative stress markers: a prospective clinical trial.BMC oral health · 2024Trial
- Biomarkers of Oxidative and Mitochondrial Stress Are Associated With Accelerated Pace of Aging at Midlife in a Birth Cohort.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Gingival Enlargement Associated with Orthodontics Appliance Increases Protein Carbonylation and Alters Phosphorylation of Salivary Proteome.Dentistry journal · 2024Article
- Hereditary hemochromatosis with homozygous C282Y HFE mutation: possible clinical model to assess effects of elevated reactive oxygen species on the development of cardiovascular disease.Molecular and cellular biochemistry · 2024Review
- ROS signaling in innate immunity via oxidative protein modifications.Frontiers in immunology · 2024Review
- Basal autophagic flux measured in blood correlates positively with age in adults at increased risk of type 2 diabetes.GeroScience · 2023Observational
- Birth size and the serum level of biological age markers in men.Scientific reports · 2023Article
- Estimation of Redox Status in Military Pilots during Hypoxic Flight-Simulation Conditions-A Pilot Study.Antioxidants (Basel, Switzerland) · 2022Article
- Young and Undamaged rMSA Improves the Healthspan and Lifespan of Mice.Biomolecules · 2021Article
- Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases.Redox biology · 2021Review
- Porcine Breed, Sex, and Production Stage Influence the Levels of Health Status Biomarkers in Saliva Samples.Frontiers in veterinary science · 2019Article
- Effect ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Review
- Aging related changes in circulating reactive oxygen species (ROS) and protein carbonyls are indicative of liver oxidative injury.Toxicology reports · 2018Article
- Colony stimulating factor-1 in saliva in relation to age, smoking, and oral and systemic diseases.Scientific reports · 2017Article
- Redox theory of aging: implications for health and disease.Clinical science (London, England : 1979) · 2017Review
- Oxidative Damage to the Salivary Glands of Rats with Streptozotocin-Induced Diabetes-Temporal Study: Oxidative Stress and Diabetic Salivary Glands.Journal of diabetes research · 2016Article
- Salivary markers of oxidative stress in oral diseases.Frontiers in cellular and infection microbiology · 2015Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Free radical hypothesis which is one of the most acknowledged aging theories was developed into oxidative stress hypothesis. Protein carbonylation is by far one of the most widely used markers of protein oxidation. We studied the role of age and gender in protein carbonyl content of saliva and plasma among 273 Chinese healthy subjects (137 females and 136 males aged between 20 and 79) and discussed the correlation between protein carbonyl content of saliva and plasma. Protein carbonyl content of saliva and plasma were, respectively, 2.391 ± 0.639 and 0.838 ± 0.274 nmol/mg. Variations of saliva and plasma different age groups all reached significant differences in both male and female (all p < 0.05) while both saliva and plasma protein carbonyls were found to be significantly correlated with age (r = 0.6582 and r = 0.5176, all p < 0.001). Gender was discovered to be unrelated to saliva and plasma protein carbonyl levels (all p > 0.05). Saliva and plasma protein carbonyls were positively related (r = 0.4405, p < 0.001). Surprisingly, saliva and plasma protein carbonyls/ferric reducing ability of plasma (FRAP) ratios were proved to be significantly correlated with age (r = 0.7796 and r = 0.6938, all p < 0.001) while saliva protein carbonyls/FRAP ratio and plasma protein carbonyls/FRAP ratio were also correlated (r = 0.5573, p < 0.001). We concluded that saliva protein carbonyls seem to be an alternative biomarker of aging while the mechanisms of protein carbonylation and oxidative stress and the relationship between saliva protein carbonyls and diseases need to be further investigated.
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