ArticleGenes & nutrition2015
Olfactory receptor genes cooperate with protocadherin genes in human extreme obesity.
Article in Genes & nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Adipose tissue gene expression is differentially regulated with different rates of weight loss in overweight and obese humans.International journal of obesity (2005) · 2017Trial
- The Role of the Olfactory System in Obesity and Metabolism in Humans: A Systematic Review and Meta-Analysis.Metabolites · 2023Review
- Similar proteome expression profiles of the aggregated lymphoid nodules area and Peyer's patches in Bactrian camel.BMC genomics · 2023Article
- DNA methylation and waist-to-hip ratio: an epigenome-wide association study in Chinese monozygotic twins.Journal of endocrinological investigation · 2022Article
- Copy number variant analysis and expression profiling of the olfactory receptor-rich 11q11 region in obesity predisposition.Molecular genetics and metabolism reports · 2020Article
- TNFRSF12A and a new prognostic model identified from methylation combined with expression profiles to predict overall survival in hepatocellular carcinoma.Translational cancer research · 2020Article
- Obesity and COVID-19: Oro-Naso-Sensory Perception.Journal of clinical medicine · 2020Review
- Clustered Protocadherins Emerge as Novel Susceptibility Loci for Mental Disorders.Frontiers in neuroscience · 2020Review
- A Brief Review of Genetic Approaches to the Study of Food Preferences: Current Knowledge and Future Directions.Nutrients · 2019Review
- Therapeutic potential of ectopic olfactory and taste receptors.Nature reviews. Drug discovery · 2019Review
- Associations between olfactory pathway gene methylation marks, obesity features and dietary intakes.Genes & nutrition · 2019Article
- Genetics of Obesity Traits: A Bivariate Genome-Wide Association Analysis.Frontiers in genetics · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Worldwide, the incidence of obesity has increased dramatically over the past decades. More knowledge about the complex etiology of obesity is needed in order to find additional approaches for treatment and prevention. Investigating the exome sequencing data of 30 extremely obese subjects (BMI 45-65 kg/m(2)) shows that predicted damaging missense variants in olfactory receptor genes on chromosome 1q and rare predicted damaging variants in the protocadherin (PCDH) beta-cluster genes on chromosome 5q31, reported in our previous work, co-localize in subjects with extreme obesity. This implies a synergistic effect between genetic variation in these gene clusters in the predisposition to extreme obesity. Evidence for a general involvement of the olfactory transduction pathway on itself could not be found. Bioinformatic analysis indicates a specific involvement of the PCDH beta-cluster genes in controlling tissue development. Further mechanistic insight needs to await the identification of the ligands of the 1q olfactory receptors. Eventually, this may provide the possibility to manipulate food flavor in a way to reduce the risk of overeating and of extreme obesity in genetically predisposed subjects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.