ArticlePediatric radiology2015
Contribution of acoustic radiation force impulse (ARFI) elastography to the ultrasound diagnosis of biliary atresia.
Article in Pediatric radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- The diagnostic performance of ultrasound features for biliary atresia: a systematic review and updated meta-analysis.Pediatric surgery international · 2025Pooled it
- Use of shear wave elastography for the diagnosis and follow-up of biliary atresia: A meta-analysis.World journal of gastroenterology · 2022Pooled it
- Practical approach to imaging diagnosis of biliary atresia, Part 1: prenatal ultrasound and magnetic resonance imaging, and postnatal ultrasound.Pediatric radiology · 2021Pooled it
- Global research trends in biliary atresia-related liver fibrosis: a bibliometric analysis (2000-2024).Frontiers in pediatrics · 2026Article
- Diseases of bile duct in children.World journal of gastroenterology · 2024Review
- Diagnostic Efficacy of Advanced Ultrasonography Imaging Techniques in Infants with Biliary Atresia (BA): A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2022Review
- Ultrasound elastography in the diagnosis of biliary atresia in pediatric surgery: a systematic review and meta-analysis of diagnostic test.Translational pediatrics · 2022Article
- Neonatal diagnosis of biliary atresia: a practical review and update.Pediatric radiology · 2022Review
- Ultrasound for the Diagnosis of Biliary Atresia: From Conventional Ultrasound to Artificial Intelligence.Diagnostics (Basel, Switzerland) · 2021Review
- Review
- Acoustic radiation force impulse imaging: normal values of spleen stiffness in healthy children.Pediatric radiology · 2021Article
- Three-color risk stratification for improving the diagnostic accuracy for biliary atresia.European radiology · 2020Article
- Neonatal cholestasis: emerging molecular diagnostics and potential novel therapeutics.Nature reviews. Gastroenterology & hepatology · 2019Review
- MRI-based decision tree model for diagnosis of biliary atresia.European radiology · 2018Article
- Feasibility of 2-D ultrasound shear wave elastography of fetal lungs in case of threatened preterm labour: a study protocol.BMJ open · 2017Article
- Ultrasound of congenital and inherited disorders of the pediatric hepatobiliary system, pancreas and spleen.Pediatric radiology · 2017Review
- Limitations and opportunities of non-invasive liver stiffness measurement in children.World journal of hepatology · 2017Review
- ARFI: from basic principles to clinical applications in diffuse chronic disease-a review.Insights into imaging · 2016Review
- Quantitative Shear-Wave Elastography of the Liver in Preterm Neonates with Intra-Uterine Growth Restriction.PloS one · 2015Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildren with biliary atresia rapidly develop liver fibrosis secondary to inflammatory destruction of the biliary tract. Noninvasive detection of liver fibrosis in neonatal/infantile cholestasis is an additional criterion for the diagnosis of biliary atresia, leading to prompt surgical exploration.
objectiveTo assess the value of US with acoustic radiation force impulse (ARFI) elastography to detect biliary atresia in the workup of neonatal/infantile cholestasis. MATERIALS AND
methodsIn this retrospective study, 20 children with cholestasis suspected of having biliary atresia were investigated by US and ARFI. We evaluated the association between US findings and the diagnosis of biliary atresia and with two scores of liver fibrosis obtained from liver biopsy.
resultsIn univariate analyses, gallbladder size, triangular cord sign, spleen size and ARFI values were found to be associated with biliary atresia, though only the triangular cord sign remained significant when elevated gamma glutamyltransferase (GGT) was included as a predictor. In contrast, spleen size and ARFI correlated with the degree of liver fibrosis on biopsy (r > 0.70, P < 0.001), which remained significant when gamma glutamyltransferase elevation was included as a predictor.
conclusionThe addition of ARFI to a standard abdominal US in the initial workup of the neonate with possible infantile cholestasis can provide reliable information on liver fibrosis and help in the diagnosis of biliary atresia.
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