ArticleExperimental neurology2015
Modeling early-onset post-ischemic seizures in aging mice.
Article in Experimental neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Post-stroke seizures in animal models: a systematic review and meta-analysis.Frontiers in neuroscience · 2025Pooled it
- Association between seizures after ischemic stroke and stroke outcome: A systematic review and meta-analysis.Medicine · 2016Pooled it
- ROS Activated NETosis of Bone Marrow CD55Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- The novel ROCK2 selective inhibitor NRL-1049 preserves the blood-brain barrier after acute injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Hippocampal infarction and generalized seizures predict early mortality after endovascular middle cerebral artery occlusion in mice.Experimental neurology · 2024Article
- Can Old Animals Reveal New Targets? The Aging and Degenerating Brain as a New Precision Medicine Opportunity for Epilepsy.Frontiers in neurology · 2022Review
- Epileptiform activity in mouse hippocampal slices induced by moderate changes in extracellular MgBMC neuroscience · 2021Article
- Electrographic Features of Spontaneous Recurrent Seizures in a Mouse Model of Extended Hippocampal Kindling.Cerebral cortex communications · 2021Article
- Role of microRNA-155 in modifying neuroinflammation and γ-aminobutyric acid transporters in specific central regions after post-ischaemic seizures.Journal of cellular and molecular medicine · 2019Article
- mTOR is involved in stroke-induced seizures and the anti-seizure effect of mild hypothermia.Molecular medicine reports · 2018Article
- Contributions of the Hippocampal CA3 Circuitry to Acute Seizures and Hyperexcitability Responses in Mouse Models of Brain Ischemia.Frontiers in cellular neuroscience · 2018Article
- Susceptibility to hippocampal kindling seizures is increased in aging C57 black mice.IBRO reports · 2017Article
- Continuous Monitoring via Tethered Electroencephalography of Spontaneous Recurrent Seizures in Mice.Frontiers in behavioral neuroscience · 2017Article
- Early-Onset Convulsive Seizures Induced by Brain Hypoxia-Ischemia in Aging Mice: Effects of Anticonvulsive Treatments.PloS one · 2015Article
- Stroke-Onset Seizures During Midbrain Infarction in a Patient With Top of the Basilar Syndrome.Journal of investigative medicine high impact case reportsArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Stroke is the leading cause of seizures and epilepsy in the aged population, with post-stroke seizures being a poor prognostic factor. The pathological processes underlying post-stroke seizures are not well understood and studies of these seizures in aging/aged animals remain scarce. Therefore, our primary objective was to model post-stroke seizures in aging mice (C57 black strain, 16-20 months-old), with a focus on early-onset, convulsive seizures that occur within 24-hours of brain ischemia. We utilized a middle cerebral artery occlusion model and examined seizure activity and brain injury using combined behavioral and electroencephalographic monitoring and histological assessments. Aging mice exhibited vigorous convulsive seizures within hours of the middle cerebral artery occlusion. These seizures manifested with jumping, rapid running, barrel-rolling and/or falling all in the absence of hippocampal-cortical electrographic discharges. Seizure development was closely associated with severe brain injury and acute mortality. Anticonvulsive treatments after seizure occurrence offered temporary seizure control but failed to improve animal survival. A separate cohort of adult mice (6-8 months-old) exhibited analogous early-onset convulsive seizures following the middle cerebral artery occlusion but had better survival outcomes following anticonvulsive treatment. Collectively, our data suggest that early-onset convulsive seizures are a result of severe brain ischemia in aging animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.