ReviewAlcohol (Fayetteville, N.Y.)2015
Clock genes × stress × reward interactions in alcohol and substance use disorders.
Review in Alcohol (Fayetteville, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 64 citations in OpenAlex.
- The Role of Melatonin in Smoking Cessation and COPD Management: A Randomized Controlled Trial.Canadian respiratory journal · 2026Trial
- Mediodorsal thalamus of alcohol-dependent mice shows genetic and physiological adaptations and alcohol-biased calcium signaling.Neuropharmacology · 2026Article
- Timing matters: circadian rhythm disruption in alcohol-associated peripheral organ pathophysiology.Function (Oxford, England) · 2026Review
- Clock Gene Expression Modulation by Low- and High-Intensity Exercise Regimens in Aging Mice.International journal of molecular sciences · 2025Article
- DAILY - A personalized circadianFrontiers in psychiatry · 2025Article
- Exploring the association between melatonin and nicotine dependence (Review).International journal of molecular medicine · 2024Review
- Effects of chronodisruption and alcohol consumption on gene expression in reward-related brain areas in female rats.Frontiers in molecular neuroscience · 2024Article
- A Complex Relationship Among the Circadian Rhythm, Reward Circuit and Substance Use Disorder (SUD).Psychology research and behavior management · 2024Review
- A translationally informed approach to vital signs for psychiatry: a preliminary proof of concept.NPP - digital psychiatry and neuroscience · 2024Article
- A Three-Way Interaction of Sex, PER2Genes · 2023Article
- Differential Effects of Cocaine and Morphine on the Diurnal Regulation of the Mouse Nucleus Accumbens Proteome.Journal of proteome research · 2023Article
- The Medication Use Issues and Challenges of Mental Illness Exacerbation in Patients with Schizophrenia: A Qualitative Study in Thailand.Patient preference and adherence · 2023Article
- Astrocyte Molecular Clock Function in the Nucleus Accumbens Is Important for Reward-Related Behavior.Biological psychiatry · 2022Article
- The effects of circadian desynchronization on alcohol consumption and affective behavior during alcohol abstinence in female rats.Frontiers in behavioral neuroscience · 2022Article
- Circadian Characteristics in Patients under Treatment for Substance Use Disorders and Severe Mental Illness (Schizophrenia, Major Depression and Bipolar Disorder).Journal of clinical medicine · 2021Article
- Article
- Diurnal changes in perineuronal nets and parvalbumin neurons in the rat medial prefrontal cortex.Brain structure & function · 2021Article
- Female mice are more prone to develop an addictive-like phenotype for sugar consumption.Scientific reports · 2021Article
- Influence ofJournal of personalized medicine · 2020Article
- DAILY-A Personalized CircadianFrontiers in psychiatry · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Adverse life events and highly stressful environments have deleterious consequences for mental health. Those environmental factors can potentiate alcohol and drug abuse in vulnerable individuals carrying specific genetic risk factors, hence producing the final risk for alcohol- and substance-use disorders development. The nature of these genes remains to be fully determined, but studies indicate their direct or indirect relation to the stress hypothalamo-pituitary-adrenal (HPA) axis and/or reward systems. Over the past decade, clock genes have been revealed to be key-players in influencing acute and chronic alcohol/drug effects. In parallel, the influence of chronic stress and stressful life events in promoting alcohol and substance use and abuse has been demonstrated. Furthermore, the reciprocal interaction of clock genes with various HPA-axis components, as well as the evidence for an implication of clock genes in stress-induced alcohol abuse, have led to the idea that clock genes, and Period genes in particular, may represent key genetic factors to consider when examining gene × environment interaction in the etiology of addiction. The aim of the present review is to summarize findings linking clock genes, stress, and alcohol and substance abuse, and to propose potential underlying neurobiological mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.